Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 4/20 | 0.31 |
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7918549 | 1.00 | SPHK2 (0.31) | SPHK2SPHK1CNR2 | |
| SCHEMBL7918053 | 0.77 | CYP2D6 (0.40) | — | |
| SCHEMBL7918057 | 0.77 | CYP2D6 (0.40) | — | |
| SCHEMBL25291699 | 0.75 | PDK1 (0.36) | CNR2 | |
| SCHEMBL12464684 | 0.75 | PDK1 (0.36) | CNR2 | |
| SCHEMBL24937205 | 0.75 | PDK1 (0.36) | CNR2 | |
| Hydrochloric Acid SCHEMBL6133032 | 0.74 | PDK1 (0.36) | CNR2 | |
| SCHEMBL29318365 | 0.72 | CNR2 (0.32) | CNR2 | |
| SCHEMBL19860656 | 0.72 | CNR2 (0.32) | CNR2 | |
| SCHEMBL28162872 | 0.72 | LMNA (0.38) | SPHK2SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221865-B1 | INHIBITORS OF PROTEIN FARNESYLTRANSFERASE AND PROTEIN GERANYLGERANYLTRANSFERASE. | UNIVERSITY OF PITTSBURGH | 2001-04-24 | — | — | US | disclosed |
| WO-1998050030-A1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 1998-11-12 | — | — | WO | disclosed |