Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7918389 | 0.90 | HTR1A (0.48) | HTR1AKDM4EALDH1A1HPGDPRKCA | |
| SCHEMBL7919024 | 0.84 | KDM4E (0.46) | HTR1AKDM4EALDH1A1HPGDADRA1D | |
| SCHEMBL6963955 | 0.79 | HTR1A (0.43) | HTR1ATP53MAPT | |
| SCHEMBL7918563 | 0.77 | HTR1A (0.42) | HTR1AALDH1A1HPGDADRA1DADRA1A | |
| SCHEMBL7920801 | 0.75 | KDM4E (0.42) | HTR1AKDM4EALDH1A1HPGDADRA1D | |
| SCHEMBL8031227 | 0.75 | HTR1A (0.41) | HTR1AALDH1A1HPGDADRA1DADRA1A | |
| SCHEMBL7911455 | 0.74 | GRM2 (0.40) | HTR1AKDM4EALDH1A1HPGDADRA1D | |
| SCHEMBL4596960 | 0.72 | HPGD (0.56) | HTR1AKDM4EALDH1A1HPGD | |
| SCHEMBL6626738 | 0.70 | KDM4E (0.48) | HTR1AKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL7464571 | 0.70 | ADRA1D (0.58) | HTR1AKDM4EALDH1A1HPGDADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221863-B1 | TREATING DEPRESSION IN A PATIENT | AMERICAN HOME PRODUCTS CORP. | 2001-04-24 | — | — | US | disclosed |
| WO-2000040581-A1 | 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |