Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 4/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.36 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3205346 | 0.88 | UCHL1 (0.44) | RORCKDM1AHDAC1HDAC6 | |
| SCHEMBL30479646 | 0.88 | UCHL1 (0.44) | RORCKDM1AHDAC1HDAC6 | |
| SCHEMBL7911444 | 0.82 | ALDH1A1 (0.38) | ALDH1A1HPGDRORCMAPTHTR1A | |
| SCHEMBL6975852 | 0.81 | RORC (0.45) | RORCTP53MAPTKDM1AMEN1 | |
| SCHEMBL7919024 | 0.77 | KDM4E (0.46) | KDM4EALDH1A1HPGDPRKCADRD2 | |
| SCHEMBL6977474 | 0.76 | MAPT (0.44) | ALDH1A1RORCTP53MAPT | |
| SCHEMBL7918936 | 0.75 | HTR1A (0.47) | KDM4EALDH1A1HPGDPRKCATP53 | |
| SCHEMBL22396991 | 0.74 | RORC (0.52) | RORCTP53MAPT | |
| SCHEMBL22396988 | 0.74 | RORC (0.52) | RORCTP53MAPT | |
| SCHEMBL22397004 | 0.74 | RORC (0.52) | RORCTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221863-B1 | TREATING DEPRESSION IN A PATIENT | AMERICAN HOME PRODUCTS CORP. | 2001-04-24 | — | — | US | disclosed |
| WO-2000040581-A1 | 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |