Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 10/20 | 0.45 |
| ▸ | EHMT1 | Q9H9B1 | 4/20 | 0.45 |
| ▸ | NSD2 | O96028 | 3/20 | 0.45 |
| ▸ | NSD3 | Q9BZ95 | 3/20 | 0.45 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2176843 | 0.95 | EHMT2 (0.46) | EHMT2EHMT1NSD2NSD3EZH2 | |
| SCHEMBL13333056 | 0.93 | ADRA1A (0.53) | ADRA1AADRA1B | |
| SCHEMBL13333113 | 0.90 | ADRA1A (0.43) | EHMT2EHMT1NSD2NSD3EZH2 | |
| SCHEMBL2172355 | 0.89 | EHMT2 (0.49) | EHMT2EHMT1NSD2NSD3EZH2 | |
| SCHEMBL2171720 | 0.89 | WHR1 (0.42) | EHMT2EHMT1NSD2NSD3EZH2 | |
| SCHEMBL14715370 | 0.88 | EHMT2 (0.44) | EHMT2EHMT1NSD2NSD3EZH2 | |
| SCHEMBL2176847 | 0.88 | HCRTR1 (0.45) | EHMT2EHMT1NSD2NSD3EZH2 | |
| SCHEMBL3319567 | 0.87 | ADRA1A (0.56) | ADRA1AADRA1B | |
| SCHEMBL7919891 | 0.86 | EHMT2 (0.42) | EHMT2EHMT1NSD2NSD3EZH2 | |
| SCHEMBL13333099 | 0.86 | EHMT2 (0.58) | EHMT2EHMT1NSD2NSD3EZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318749-B2 | Quinazoline derivatives as NK3 receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2012-11-27 | — | — | US | disclosed |
| US-8318749-B2 | Quinazoline derivatives as NK3 receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2012-11-27 | — | — | US | disclosed |
| US-20100125078-A1 | QUINAZOLINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2010-05-20 | — | — | US | disclosed |
| US-20100125078-A1 | QUINAZOLINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2010-05-20 | — | — | US | disclosed |
| WO-2010054968-A1 | QUINAZOLINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100125078-A1 | QUINAZOLINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | SLC6A3, OPRK1, HTR3A | EHMT2 3673/4885EHMT1 3128/4885NSD2 3069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.