Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7920060 | 0.87 | PDE7A (0.60) | MEN1KMT2APOLBGAAALDH1A1 | |
| SCHEMBL7921377 | 0.85 | GAA (0.54) | PTGESMEN1KMT2APOLBGAA | |
| SCHEMBL23879982 | 0.81 | MAPT (0.58) | PTGESMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL2728411 | 0.79 | ALDH1A1 (0.58) | MEN1KMT2APOLBALDH1A1CYP3A4 | |
| SCHEMBL5240597 | 0.79 | ALDH1A1 (0.62) | MEN1KMT2APOLBALDH1A1CYP3A4 | |
| SCHEMBL4543187 | 0.78 | KDM4E (0.53) | MEN1KMT2APOLBGAAALDH1A1 | |
| SCHEMBL19969740 | 0.77 | ALDH1A1 (0.60) | MEN1KMT2APOLBALDH1A1CYP3A4 | |
| SCHEMBL11156793 | 0.77 | ALDH1A1 (0.44) | MEN1KMT2APOLBGAAALDH1A1 | |
| SCHEMBL2963062 | 0.77 | LMNA (0.64) | MEN1KMT2APOLBGAAALDH1A1 | |
| SCHEMBL8380180 | 0.76 | ALDH1A1 (0.58) | MEN1KMT2AALDH1A1CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291442-B1 | Pharmacological modulators of voltage-gated potassium ion channels | THE GENERAL HOSPITAL CORPORATION | 2001-09-18 | — | — | US | disclosed |