Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3382999 | 0.78 | ALDH1A1 (0.53) | NR3C1PGRKDM4ETDP1ALDH1A1 | |
| SCHEMBL3357234 | 0.74 | MAPT (0.43) | NR3C1PGRKDM4ETDP1ALDH1A1 | |
| SCHEMBL6977571 | 0.73 | ALDH1A1 (0.49) | NR3C1PGRKDM4ETDP1ALDH1A1 | |
| SCHEMBL10358737 | 0.71 | NR3C1 (0.38) | NR3C1KDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL25072493 | 0.69 | ALDH1A1 (0.44) | NR3C1PGRKDM4ETDP1ALDH1A1 | |
| SCHEMBL3355386 | 0.69 | HSD17B10 (0.51) | KDM4EALDH1A1MAPTHSD17B10TSHR | |
| SCHEMBL10197624 | 0.69 | TDP2 (0.49) | NR3C1PGRKDM4EALDH1A1MAPK1 | |
| SCHEMBL5799822 | 0.69 | GAA (0.44) | KDM4ETDP1ALDH1A1L3MBTL1MEN1 | |
| SCHEMBL14087988 | 0.68 | TDP1 (0.65) | KDM4ETDP1CTDSP1ALDH1A1MAPT | |
| SCHEMBL4308779 | 0.68 | MEN1 (0.49) | NR3C1PGRKDM4ETDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221863-B1 | TREATING DEPRESSION IN A PATIENT | AMERICAN HOME PRODUCTS CORP. | 2001-04-24 | — | — | US | disclosed |
| WO-2000040581-A1 | 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |