Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 12/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.50 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | PIM1 | P11309 | 2/20 | 0.44 |
| ▸ | PRKACA | P17612 | 2/20 | 0.44 |
| ▸ | CLK2 | P49760 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.44 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5844134 | 0.74 | HTR1A (0.61) | TMEM97SIGMAR1HTR1ASLC6A4ADRA1D | |
| SCHEMBL13502652 | 0.73 | SIGMAR1 (0.68) | TMEM97SIGMAR1HTR1ASLC6A4DRD2 | |
| SCHEMBL6108012 | 0.71 | HTR1A (0.65) | TMEM97SIGMAR1HTR1ASLC6A4DRD2 | |
| SCHEMBL9529716 | 0.71 | KCNH2 (0.50) | HTR1ADRD2DRD4ADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL10368330 | 0.71 | ABCB1 (0.48) | SIGMAR1HTR1ADRD2DRD4DRD3 | |
| SCHEMBL13064304 | 0.70 | TMEM97 (0.59) | TMEM97SIGMAR1HTR1ASLC6A4DRD2 | |
| SCHEMBL9530044 | 0.69 | ABCB1 (0.49) | SIGMAR1HTR1ADRD2DRD4DRD3 | |
| SCHEMBL9696810 | 0.69 | ADRA2A (0.59) | SIGMAR1HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL7911460 | 0.69 | HTR1A (1.00) | SIGMAR1HTR1ASLC6A4DRD2HTR2A | |
| SCHEMBL9455117 | 0.69 | CASR (0.45) | TMEM97SIGMAR1HTR1ADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221863-B1 | TREATING DEPRESSION IN A PATIENT | AMERICAN HOME PRODUCTS CORP. | 2001-04-24 | — | — | US | disclosed |
| WO-2000040581-A1 | 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |