Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | SCN1A | P35498 | 1/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.46 |
| ▸ | CASR | P41180 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10368330 | 0.99 | ABCB1 (0.48) | ABCB1ADRA2AADRA2BADRA2CSIGMAR1 | |
| SCHEMBL9455117 | 0.90 | CASR (0.45) | ADRA2AADRA2BADRA2CSIGMAR1HTR1A | |
| SCHEMBL9530260 | 0.89 | SIGMAR1 (0.53) | ADRA2AADRA2BADRA2CSIGMAR1HTR1A | |
| SCHEMBL9696810 | 0.89 | ADRA2A (0.59) | ABCB1ADRA2AADRA2BADRA2CSIGMAR1 | |
| SCHEMBL9529266 | 0.88 | DRD2 (0.53) | SIGMAR1HTR1ADRD2DRD4MAPT | |
| SCHEMBL9529716 | 0.85 | KCNH2 (0.50) | ADRA2AADRA2BADRA2CHTR1ADRD2 | |
| SCHEMBL9455118 | 0.85 | ADRA2A (0.70) | ADRA2AADRA2BADRA2CHTR1ADRD2 | |
| SCHEMBL9530828 | 0.84 | KDM4E (0.45) | ABCB1ADRA2AADRA2BADRA2CSIGMAR1 | |
| SCHEMBL7937213 | 0.82 | HTR1A (0.71) | ADRA2AADRA2BADRA2CSIGMAR1HTR1A | |
| SCHEMBL9529252 | 0.78 | CASR (0.50) | HTR1AADRA1DADRA1AADRA1BCASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0359790-B1 | 1,4-BENZOXAZINE AND 1,4-BENZOTHIAZINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | ERBA CARLO SPA (IT) | 1993-11-03 | — | — | EP | disclosed |
| US-5084454-A | Tranquilizers and antinausea drugs | FARMITALIA CARLO ERBA S.R.L. (IT) | 1992-01-28 | — | — | US | disclosed |