SCHEMBL7922029

SCHEMBL7922029

CCCCSc1ccc(OB(O)O)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.45
MAOB P27338 1/20 0.45
AR P10275 2/20 0.40
MTNR1A P48039 1/20 0.40
MTNR1B P49286 1/20 0.40
THRA P10827 1/20 0.38
THRB P10828 1/20 0.38
SLC2A1 P11166 1/20 0.38
MAPT P10636 1/20 0.37
HPGD P15428 1/20 0.37
CYP3A4 P08684 2/20 0.37
CYP2C19 P33261 2/20 0.37
CYP2C9 P11712 1/20 0.37
PTGS2 P35354 2/20 0.36
RYR2 Q92736 2/20 0.36
XDH P47989 1/20 0.36
LTA4H P09960 1/20 0.36
NR5A1 Q13285 1/20 0.36
CYP1A2 P05177 1/20 0.35
CYP2D6 P10635 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7934093 0.95 THRA (0.43) MAOAMAOBARMTNR1AMTNR1B
SCHEMBL7928528 0.93 THRB (0.46) MAOAMAOBMTNR1AMTNR1BTHRA
SCHEMBL7928451 0.89 CA12 (0.43) MAOAMAOBARMTNR1AMTNR1B
SCHEMBL7922025 0.86 MAOA (0.47) MAOAMAOBARMTNR1AMTNR1B
SCHEMBL7931590 0.83 CYP1A2 (0.39) MAOAMAOBMTNR1AMTNR1BMAPT
SCHEMBL3600977 0.82 SLC6A4 (0.40) MAOAMTNR1AMTNR1BNPC1RAB9A
SCHEMBL7934090 0.81 MAOA (0.42) MAOAMAOBARMTNR1AMTNR1B
SCHEMBL2772370 0.80 LTA4H (0.55) CYP3A4LTA4HNR5A1CYP1A2CYP2D6
SCHEMBL7928525 0.79 THRB (0.44) MAOAMAOBARTHRATHRB
SCHEMBL5887468 0.79 MAOA (0.62) MAOAMAOBARTHRATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1140896-A1 BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 Takeda Chemical Industries, Ltd. (JP) 2001-10-10 EP disclosed
US-6235771-B1 AIDS THERPAY TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-05-22 US disclosed
WO-2000037455-A1 BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-06-29 WO disclosed