Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 5/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | GSR | P00390 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7922157 | 1.00 | TRPA1 (0.38) | TRPA1HRH1LMNASLC6A2SLC6A4 | |
| SCHEMBL7521698 | 0.98 | TRPA1 (0.39) | TRPA1HRH1LMNASLC6A2SLC6A4 | |
| SCHEMBL7521700 | 0.98 | TRPA1 (0.39) | TRPA1HRH1LMNASLC6A2SLC6A4 | |
| SCHEMBL5282777 | 0.77 | LMNA (0.45) | TRPA1HRH1LMNATAAR1HTR2A | |
| Hydrochloric Acid SCHEMBL28421235 | 0.75 | CYP2C19 (0.44) | L3MBTL1TAAR1KDM4EHTR2A | |
| SCHEMBL11655728 | 0.72 | CYP2C19 (0.46) | L3MBTL1TAAR1KDM4EHTR2A | |
| Hydrochloric Acid SCHEMBL1072631 | 0.71 | MEN1 (0.42) | SLC6A2SLC6A4SLC6A3HTR2A | |
| Hydrochloric Acid SCHEMBL16144879 | 0.71 | MEN1 (0.42) | SLC6A2SLC6A4SLC6A3HTR2A | |
| SCHEMBL14802083 | 0.71 | POLB (0.41) | LMNATAAR1KDM4EHTR2A | |
| Hydrochloric Acid SCHEMBL8741699 | 0.67 | TSHR (0.46) | SLC6A2SLC6A4SLC6A3L3MBTL1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6232319-B1 | TREATMENT OF MEMORY DEFECTS ASSOCIATED WITH CEREBRAL AGING AND WITH NEURODEGENERATIVE DISEASES INCLUDING ALZHEIMER'S DISEASE, PARKINSON'S DISEASE, PICK'S DISEASE, KORSAKOFF'S DISEASE AND FRONTAL AND SUBCOTICAL DEMENTIAS | ADIR ET COMPAGNIE (FR) | 2001-05-15 | — | — | US | disclosed |