Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7923573 | 0.81 | NFE2L2 (0.42) | CYP1A1CYP1B1KCNH2 | |
| SCHEMBL5552843 | 0.80 | LMNA (0.34) | GAAMEN1ALDH1A1KMT2ACCNE2 | |
| SCHEMBL8294647 | 0.80 | LMNA (0.34) | GAAMEN1ALDH1A1KMT2ACCNE2 | |
| SCHEMBL13233065 | 0.79 | GAA (0.39) | GAAALDH1A1KMT2A | |
| SCHEMBL2798301 | 0.79 | GAA (0.39) | GAAALDH1A1KMT2A | |
| SCHEMBL7921534 | 0.76 | CYP1A1 (0.49) | GAAALDH1A1CYP1A1CYP1B1 | |
| SCHEMBL11405065 | 0.75 | ALDH1A1 (0.45) | ALDH1A1CYP1A1CYP1B1IDO1KCNH2 | |
| SCHEMBL7920975 | 0.74 | ALDH1A1 (0.43) | MEN1ALDH1A1KMT2AIDO1KCNH2 | |
| SCHEMBL7921428 | 0.74 | NFE2L2 (0.45) | MEN1ALDH1A1KMT2A | |
| SCHEMBL15216528 | 0.74 | NFE2L2 (0.45) | MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194461-B1 | USEFUL AS MEDICAMENT FOR TREATING RETINAL DEGENERATIVE DISORDERS; ALPHA-(2,4-DIFLUOROPHENYL)-N-T-BUTYLNITRONE, AND CORRESPONDING AMINES WHICH WOULD BE CONVERTED IN VIVO TO THE NITRONE, FOR EXAMPLE | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-02-27 | — | — | US | disclosed |
| EP-0945426-A1 | NITRONE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-09-29 | — | — | EP | disclosed |