Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
| ▸ | FBP1 | P09467 | 2/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5552843 | 1.00 | LMNA (0.34) | LMNAMAPTALDH1A1GAAHPGD | |
| SCHEMBL14390458 | 0.82 | ALDH1A1 (0.33) | ALDH1A1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL2800845 | 0.80 | FBP1 (0.33) | FBP1 | |
| SCHEMBL7923555 | 0.80 | GAA (0.38) | ALDH1A1GAAMEN1KMT2ACCNE2 | |
| SCHEMBL8294137 | 0.80 | FBP1 (0.33) | FBP1 | |
| SCHEMBL13233065 | 0.75 | GAA (0.39) | LMNAMAPTALDH1A1GAAKMT2A | |
| SCHEMBL2798301 | 0.75 | GAA (0.39) | LMNAMAPTALDH1A1GAAKMT2A | |
| SCHEMBL2798775 | 0.74 | ALOX5 (0.39) | MAPTALDH1A1MEN1KMT2ABACE1 | |
| SCHEMBL2799552 | 0.74 | POLB (0.37) | LMNAMAPTALDH1A1ADRA2AADRA2B | |
| SCHEMBL8100291 | 0.71 | KDM4E (0.36) | ALDH1A1MEN1KMT2AADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016272-A2 | ARYL, HETEROAROMATIC AND BICYCLIC ARYL NITRONE COMPOUNDS, PRODRUGS AND PHARMACEUTICAL COMPOSITIONS OF THE SAME TO TREAT HUMAN DISORDERS | RENOVIS, INC. (US) | 2005-02-24 | — | — | WO | disclosed |