Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MC4R | P32245 | 2/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16255704 | 0.93 | KMT2A (0.52) | MAPTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL16255781 | 0.88 | TSHR (0.65) | MAPTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL7923612 | 0.87 | KMT2A (0.44) | MAPTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL12141090 | 0.87 | MAPT (0.52) | MAPTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL12139634 | 0.86 | MAPT (0.51) | MAPTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL16255703 | 0.85 | MTOR (0.48) | MAPTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL16255766 | 0.85 | MTOR (0.48) | MAPTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL10259980 | 0.81 | ALDH1A1 (0.48) | MAPTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL14765582 | 0.80 | NPC1 (0.52) | MAPTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL9565826 | 0.80 | LMNA (0.55) | MAPTLMNAALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889706-B2 | Soluble mTOR complexes and modulators thereof | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2014-11-18 | — | — | US | disclosed |
| WO-2010044885-A2 | SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2010-04-22 | — | — | WO | disclosed |