Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.75 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.69 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.65 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
| ▸ | HRH1 | P35367 | 1/20 | 0.59 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20382580 | 0.89 | LTA4H (0.86) | LTA4HSIGMAR1HRH3SLC6A3GRIN2B | |
| SCHEMBL5302082 | 0.89 | LTA4H (0.86) | LTA4HSIGMAR1HRH3SLC6A3GRIN2B | |
| SCHEMBL7366528 | 0.87 | HRH3 (0.85) | LTA4HSIGMAR1HRH3SLC6A3HRH1 | |
| SCHEMBL83687 | 0.87 | SIGMAR1 (0.86) | LTA4HSIGMAR1HRH3SLC6A3GRIN2B | |
| SCHEMBL18917604 | 0.87 | LTA4H (0.75) | LTA4HSIGMAR1HRH3SLC6A3HRH1 | |
| Hydrochloric Acid SCHEMBL8037018 | 0.85 | SIGMAR1 (0.83) | LTA4HSIGMAR1HRH3SLC6A3GRIN2B | |
| Hydrochloric Acid SCHEMBL7239522 | 0.85 | LTA4H (0.80) | LTA4HSIGMAR1HRH3SLC6A3GRIN2B | |
| Ammonia Solution, Strong SCHEMBL28704893 | 0.85 | SIGMAR1 (0.83) | LTA4HSIGMAR1HRH3SLC6A3GRIN2B | |
| Hydrochloric Acid SCHEMBL11155637 | 0.85 | LTA4H (0.69) | LTA4HSIGMAR1HRH3SLC6A3GRIN2B | |
| SCHEMBL20797123 | 0.85 | SIGMAR1 (0.81) | LTA4HSIGMAR1HRH3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594563-B1 | 2-acylaminopropanol-type glucosylceramide synthase inhibitors | GENZYME CORP (US) | 2018-07-18 | — | — | EP | disclosed |
| EP-2320886-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | GENZYME CORP (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-3078373-A1 | 2-ACYLAMINOPROPANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITOR | Genzyme Corporation (US) | 2016-10-12 | — | — | EP | disclosed |
| WO-2010039256-A1 | 2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORPORATION (US) | 2010-04-08 | — | — | WO | disclosed |
| WO-2010014554-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | GENZYME CORPORATION (US) | 2010-02-04 | — | — | WO | disclosed |
| WO-2008150486-A2 | 2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORPORATION (US) | 2008-12-11 | — | — | WO | disclosed |