Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Butabarbital. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRB3 known ✓ | P28472 | 1/20 | 0.71 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.71 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | MMP9 | P14780 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butabarbital SCHEMBL122122 | 1.00 | CYP3A4 (0.71) | CYP3A4ALDH1A1KDM4EGABRB3OPRD1 | |
| Butabarbital SCHEMBL79255 | 1.00 | CYP3A4 (0.71) | CYP3A4ALDH1A1KDM4EGABRB3OPRD1 | |
| Butabarbital SCHEMBL9862052 | 0.98 | CYP3A4 (0.69) | CYP3A4ALDH1A1KDM4EGABRB3OPRD1 | |
| Butabarbital SCHEMBL122123 | 0.98 | CYP3A4 (0.69) | CYP3A4ALDH1A1KDM4EGABRB3OPRD1 | |
| Butabarbital SCHEMBL8717769 | 0.96 | CYP3A4 (0.67) | CYP3A4ALDH1A1KDM4EGABRB3OPRD1 | |
| Pentobarbital SCHEMBL2376470 | 0.83 | CYP3A4 (1.00) | CYP3A4ALDH1A1KDM4EGABRB3OPRD1 | |
| Pentobarbital SCHEMBL735353 | 0.83 | CYP3A4 (1.00) | CYP3A4ALDH1A1KDM4EGABRB3OPRD1 | |
| SCHEMBL120257 | 0.83 | LMNA (0.73) | CYP3A4ALDH1A1KDM4EGABRB3OPRD1 | |
| SCHEMBL9305362 | 0.83 | CYP3A4 (0.67) | CYP3A4ALDH1A1KDM4EGABRB3OPRD1 | |
| SCHEMBL120258 | 0.83 | LMNA (0.73) | CYP3A4ALDH1A1KDM4EGABRB3OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 9426 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260041939-A1 | METHODS FOR THE TREATMENT OF HYPERTENSION VIA TRANSCRANIAL-FOCUSED-ULTRASOUND | SUNNYBROOK RES INST (CA) | 2026-02-12 | — | — | US | claimed |
| US-20250249002-A1 | PHARMACEUTICAL COMPOSITION FOR TOPICAL WOUND TREATMENT | CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECN (AR) | 2025-08-07 | — | — | US | claimed |
| CN-119110564-B | Three-dimensional vapor chamber and manufacturing method thereof | 微通新材料科学研究(江苏)有限公司 | 2025-03-07 | — | — | CN | claimed |
| EP-3441087-B1 | METHODS OF TREATING CHRONIC PAIN | TEVA PHARMACEUTICALS INT GMBH (CH) | 2025-02-19 | — | — | EP | claimed |
| CN-119110564-A | Three-dimensional vapor chamber and manufacturing method thereof | 微通新材料科学研究(江苏)有限公司 | 2024-12-10 | — | — | CN | claimed |
| US-20240390364-A1 | Novel Pyridine Compositions and their use in methods for preventing or treating diseases, disorders and conditions | REID CHRISTOPHER BRIAN (US) | 2024-11-28 | — | — | US | claimed |
| US-12133922-B2 | Abuse resistant capsule | R.P. SCHERER TECHNOLOGIES, LLC (US) | 2024-11-05 | — | — | US | claimed |
| CN-111432873-B | Treatment of type 1 diabetes | 加尔瓦尼生物电子有限公司 | 2024-08-13 | — | — | CN | claimed |
| US-20240238250-A1 | METHOD OF USING PIROMELATINE FOR TREATING PARASOMNIAS ASSOCIATED WITH LOSS OF REM SLEEP ATONIA | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2024-07-18 | — | — | US | claimed |
| WO-2024150170-A1 | PIROMELATINE FOR TREATING PARASOMNIAS ASSOCIATED WITH LOSS OF REM SLEEP ATONIA | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2024-07-18 | — | — | WO | claimed |
| CN-1007904-B | Hot melt adhesive for bonding steel pipe yellow jacket | NEW MATERIALS INST SHANDONG PR (CN) | 1990-05-09 | — | — | CN | claimed |
| CN-1041963-A | Microscope liquid immersion oil and preparation method thereof | FOREST PRODUCTS CHEMICAL INDUS (CN) | 1990-05-09 | — | — | CN | claimed |
| CN-1041354-A | MULTI-EFFECT FERTILIZER FOR KILLING INSECTS AND RESISTING WITHERING | ZHANG YUEBO (CN) | 1990-04-18 | — | — | CN | claimed |
| CN-88101383-A | HIGH SOLIDS PSA COMPOUNDS | — | 1988-10-05 | — | — | CN | claimed |
| CN-86107790-A | A kind of hot melt adhesive | — | 1988-04-06 | — | — | CN | claimed |
| CN-85109217-A | HOT MELTING ADHESIVE FOR POLYOLEFIN | — | 1987-06-17 | — | — | CN | claimed |
| US-4244939-A | RADIOIMMUNOASSAY | BAXTER TRAVENOL LABORATORIES, INC. (US) | 1981-01-13 | — | — | US | claimed |
| US-4175119-A | Composition and method to prevent accidental and intentional overdosage with psychoactive drugs | PORTER GARRY L | 1979-11-20 | — | — | US | claimed |
| US-RE29875-E | THEOPHYLLINE SOLUBILIZED BY GLYCERYL GUAIACOLATE, POTASSIUM GUAIACOL SULFONATE OR GUAIACOL | MEAD JOHNSON & COMPANY (US) | 1979-01-02 | — | — | US | claimed |
| US-4126684-A | 4-AMINO-3-P-HALOPHENYLBUTYRIC ACIDS AND THEIR DERIVATIVES USED IN THE CONTROL OF NARCOTIC ABUSE | CIBA-GEIGY CORPORATION (US) | 1978-11-21 | — | — | US | claimed |