Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | CCR3 | P51677 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7925969 | 0.75 | CCR3 (0.62) | MAPTKDM4EALOX15CCR3ALDH1A1 | |
| SCHEMBL14593345 | 0.74 | KDM4E (0.51) | MAPTKDM4EHPGDHSD17B10ALOX15 | |
| SCHEMBL16501809 | 0.71 | CCR3 (0.49) | MAPTKDM4ECCR3ALDH1A1GFER | |
| SCHEMBL11612020 | 0.71 | ACHE (0.51) | MAPTKDM4EHPGDHSD17B10ALOX15 | |
| SCHEMBL7236813 | 0.69 | OPRL1 (0.49) | MAPTKDM4EHSD17B10ALOX15SMN1; SMN2 | |
| SCHEMBL10438555 | 0.69 | DRD2 (0.58) | MAPTKDM4ESMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL16796793 | 0.69 | ALDH1A1 (0.47) | MAPTKDM4EHPGDHSD17B10ALOX15 | |
| SCHEMBL7925962 | 0.69 | CCR3 (0.55) | MAPTKDM4EALOX15CCR3ALDH1A1 | |
| SCHEMBL11614698 | 0.68 | ACHE (0.55) | MAPTKDM4EHPGDHSD17B10ALOX15 | |
| SCHEMBL9717662 | 0.67 | CA1 (0.46) | MAPTKDM4EHPGDHSD17B10ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235732-B1 | RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; SKIN DISORDERS | BOEHRINGER INGELHEIM KG (DE) | 2001-05-22 | — | — | US | disclosed |
| US-6191135-B1 | Neurokinin antagonists | BOEHRINGER INGELHEIM KG (DE) | 2001-02-20 | — | — | US | disclosed |
| US-5985881-A | TREATMENT AND PREVENTION OF RESPIRATORY DISORDERS, INFLAMMATORY EYE DISEASES, INFLAMMATORY SKIN DISEASES, INTESTINAL DISORDERS, OTHER INFLAMMATORY DISEASES | BOEHRINGER INGELHEIM KG (DE) | 1999-11-16 | — | — | US | disclosed |
| US-5708006-A | ANTIINFLAMMATORY AGENTS | BOEHRINGER INGELHEIM KG (DE) | 1998-01-13 | — | — | US | disclosed |
| US-5696123-A | ALPHA-PIPERAZINYL BENZYL COMPOUND AS TACHYKININ ANTAGONIST TREATING ASTHMA, BRONCHITIS, SKIN DISORDER, EYE DISEASE, HEADACHE, GASTROINTESTINAL DISORDER | BOEHRINGER INGELHEIM KG (DE) | 1997-12-09 | — | — | US | disclosed |
| EP-0781277-A1 | NEUROKININ ANTAGONISTS | BOEHRINGER INGELHEIM KG (DE) | 1997-07-02 | — | — | EP | disclosed |
| WO-1996008480-A1 | NEUROKININ ANTAGONISTS | BOEHRINGER INGELHEIM KG (DE) | 1996-03-21 | — | — | WO | disclosed |