Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | RBBP9 | O75884 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8169909 | 0.96 | ALDH1A1 (0.32) | ALDH1A1SMN1; SMN2CHRM2CHRM4CHRM1 | |
| Hydrochloric Acid SCHEMBL7928644 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL7924556 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL7919467 | 0.72 | ALDH1A1 (0.32) | ALDH1A1SMN1; SMN2CHRM2CHRM4CHRM1 | |
| Hydrochloric Acid SCHEMBL7928625 | 0.72 | L3MBTL1 (0.30) | — | |
| SCHEMBL7930864 | 0.72 | POLB (0.33) | ALDH1A1SMN1; SMN2CHRM2CHRM4CHRM1 | |
| SCHEMBL7928375 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL7927340 | 0.71 | ALDH1A1 (0.31) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7919488 | 0.71 | — | — | |
| SCHEMBL7927226 | 0.70 | POLB (0.32) | ALDH1A1SMN1; SMN2CHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0867454-B1 | POLYMERIZATION CATALYST AND PROCESS FOR PRODUCING POLYMERS | IDEMITSU KOSAN CO (JP) | 2001-03-21 | — | — | EP | disclosed |
| US-6075102-A | Polymerization catalyst and process for producing polymers | IDEMITSU KOSAN CO., LTD. (JP) | 2000-06-13 | — | — | US | disclosed |
| EP-0867454-A1 | POLYMERIZATION CATALYST AND PROCESS FOR PRODUCING POLYMERS | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1998-09-30 | — | — | EP | disclosed |