Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979974 | 1.00 | SMN1; SMN2 (0.39) | SMN1; SMN2HPGDLMNAKMT2AMAPT | |
| SCHEMBL6942458 | 0.84 | ADAM17 (0.37) | KMT2AMAPTALDH1A1MAPK1RECQL | |
| SCHEMBL6943368 | 0.84 | ADAM17 (0.37) | KMT2AMAPTALDH1A1MAPK1RECQL | |
| SCHEMBL6982391 | 0.79 | RAB9A (0.41) | SMN1; SMN2LMNAMAPTNPC1RAB9A | |
| SCHEMBL6979636 | 0.78 | ADAM17 (0.35) | KMT2AMAPTALDH1A1MAPK1RECQL | |
| SCHEMBL6986700 | 0.77 | PSMB5 (0.36) | KMT2AMAPTALDH1A1MAPK1RECQL | |
| SCHEMBL6983531 | 0.77 | REN (0.41) | MAPTMAPK1KDM4EPOLB | |
| SCHEMBL6986242 | 0.76 | TDP1 (0.33) | KMT2AMAPTALDH1A1RECQLMEN1 | |
| SCHEMBL6981635 | 0.76 | MAPT (0.35) | KMT2AMAPTALDH1A1MAPK1RECQL | |
| SCHEMBL6984926 | 0.74 | REN (0.39) | KMT2AMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |