Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 2/20 | 0.49 |
| ▸ | F10 | P00742 | 2/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.49 |
| ▸ | F7 | P08709 | 2/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.49 |
| ▸ | F3 | P13726 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7930108 | 0.87 | KMT2A (0.57) | SMPD1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL15172218 | 0.80 | SMPD1 (0.60) | SMPD1HDAC1HDAC8HDAC6KDM4E | |
| SCHEMBL11082078 | 0.78 | SMPD1 (0.66) | SMPD1HDAC1HDAC8HDAC6KDM4E | |
| SCHEMBL6578728 | 0.78 | KDM4E (0.73) | SMPD1HDAC1HDAC8HDAC6KDM4E | |
| SCHEMBL28325672 | 0.78 | SMPD1 (0.90) | SMPD1HDAC1HDAC8HDAC6KDM4E | |
| SCHEMBL24077087 | 0.78 | SMPD1 (0.72) | SMPD1HDAC1HDAC8HDAC6KDM4E | |
| SCHEMBL9416636 | 0.76 | SMPD1 (0.70) | SMPD1HDAC1HDAC8HDAC6KDM4E | |
| SCHEMBL7930156 | 0.76 | HPGD (0.57) | HDAC1HDAC8HDAC6KDM4EMEN1 | |
| SCHEMBL9416543 | 0.76 | SMPD1 (0.70) | SMPD1HDAC1HDAC8HDAC6KDM4E | |
| SCHEMBL29066097 | 0.76 | SMN1; SMN2 (0.71) | SMPD1HDAC1HDAC8HDAC6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228868-B1 | ANTICARCINOGENIC AND ANTITUMOR AGENTS | ABBOTT LABORATORIES | 2001-05-08 | — | — | US | disclosed |