Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7940249 | 0.91 | SMN1; SMN2 (0.52) | SMN1; SMN2ADORA2AADORA1CYP1A2CYP1A1 | |
| SCHEMBL6050235 | 0.88 | MIF (0.46) | ADORA2AADORA1CYP1A2CYP1A1CYP1B1 | |
| SCHEMBL6050365 | 0.84 | CYP1A2 (0.43) | CYP1A2CYP1A1CYP1B1CYP3A4CYP2C9 | |
| SCHEMBL7937975 | 0.84 | MEN1 (0.47) | SMN1; SMN2ADORA2AADORA1KDM1AALDH1A1 | |
| SCHEMBL7937717 | 0.82 | ABCG2 (0.49) | SMN1; SMN2CYP1A2CYP1A1CYP1B1BRD4 | |
| SCHEMBL7937708 | 0.82 | SMN1; SMN2 (0.45) | SMN1; SMN2CYP1A2CYP1A1CYP1B1CYP3A4 | |
| SCHEMBL7928912 | 0.81 | ABCG2 (0.48) | SMN1; SMN2CYP1A2KDM1ACYP3A4CYP2C9 | |
| SCHEMBL7935041 | 0.81 | ADORA2A (0.45) | ADORA2AADORA1CYP1A2KDM1ACYP3A4 | |
| SCHEMBL8500385 | 0.81 | TDP1 (0.47) | CYP1A2CYP1A1CYP1B1BRD4GPR84 | |
| SCHEMBL8500390 | 0.80 | AKR1C3 (0.58) | CYP1A2CYP2C19GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835868-B1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | LILLY CO ELI (US) | 2001-08-29 | — | — | EP | disclosed |
| US-5929090-A | NOVEL COMPOUNDS FOR TREATING ESTROGEN DEPRIVATION CAUSED BY MENOPAUSE OR OVARIECTOMY; TREATING OSTEOPOROSIS, CARDIOVASCULAR DISEASES, AND ENDOMETRIOSIS | ELI LILLY AND COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| EP-0835868-A1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |