Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.39 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.39 |
| ▸ | CYP2A7 | P20853 | 1/20 | 0.39 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.39 |
| ▸ | CYP2F1 | P24903 | 1/20 | 0.39 |
| ▸ | CYP2C18 | P33260 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4F8 | P98187 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7940249 | 0.90 | SMN1; SMN2 (0.52) | SMN1; SMN2CYP3A4CYP1A1CYP1A2CYP2E1 | |
| SCHEMBL7188354 | 0.85 | RELA (0.42) | CYP3A4CYP1A1CYP1A2CYP2E1CYP2C8 | |
| SCHEMBL7934940 | 0.84 | SMN1; SMN2 (0.45) | SMN1; SMN2CYP3A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7935034 | 0.84 | PLAU (0.40) | SMN1; SMN2MAOBAPP | |
| SCHEMBL7928761 | 0.83 | DHFR (0.39) | SMN1; SMN2CYP3A4CYP1A1CYP1A2CYP2E1 | |
| SCHEMBL7937985 | 0.83 | DHFR (0.41) | SMN1; SMN2CYP3A4CYP1A1CYP1A2CYP2E1 | |
| SCHEMBL7928856 | 0.82 | SMN1; SMN2 (0.51) | SMN1; SMN2CYP3A4CYP1A1CYP1A2CYP2E1 | |
| SCHEMBL7190347 | 0.81 | ESR1 (0.52) | ESR1ESR2 | |
| SCHEMBL7190349 | 0.81 | ESR1 (0.52) | ESR1ESR2 | |
| SCHEMBL8500250 | 0.81 | KDM4E (0.38) | SMN1; SMN2CYP3A4CYP1A2CYP2C19ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835868-B1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | LILLY CO ELI (US) | 2001-08-29 | — | — | EP | disclosed |
| US-5929090-A | NOVEL COMPOUNDS FOR TREATING ESTROGEN DEPRIVATION CAUSED BY MENOPAUSE OR OVARIECTOMY; TREATING OSTEOPOROSIS, CARDIOVASCULAR DISEASES, AND ENDOMETRIOSIS | ELI LILLY AND COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| EP-0835868-A1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |