Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.42 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.42 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.42 |
| ▸ | CYP2A7 | P20853 | 1/20 | 0.42 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.42 |
| ▸ | CYP2F1 | P24903 | 1/20 | 0.42 |
| ▸ | CYP2C18 | P33260 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7928856 | 0.91 | SMN1; SMN2 (0.51) | SMN1; SMN2CYP3A4CYP1A1CYP1A2CYP2E1 | |
| SCHEMBL7937708 | 0.90 | SMN1; SMN2 (0.45) | SMN1; SMN2CYP19A1CYP3A4CYP1A1CYP1A2 | |
| SCHEMBL7934940 | 0.88 | SMN1; SMN2 (0.45) | SMN1; SMN2CYP3A4GSTP1CYP1A2CYP2D6 | |
| SCHEMBL6050136 | 0.87 | ESR1 (0.50) | CYP3A4GSTP1CYP1A1CYP1A2CYP2E1 | |
| SCHEMBL7937022 | 0.85 | MAPT (0.44) | SMN1; SMN2CYP19A1GSTP1ALDH1A1MEN1 | |
| SCHEMBL6050146 | 0.84 | GSTP1 (0.43) | SMN1; SMN2CYP3A4GSTP1CYP1A1CYP1A2 | |
| SCHEMBL7935076 | 0.82 | ESR1 (0.40) | SMN1; SMN2CYP19A1CYP3A4GSTP1CYP1A1 | |
| SCHEMBL7937985 | 0.82 | DHFR (0.41) | SMN1; SMN2CYP19A1CYP3A4GSTP1CYP1A1 | |
| SCHEMBL7928761 | 0.82 | DHFR (0.39) | SMN1; SMN2CYP19A1CYP3A4GSTP1CYP1A1 | |
| SCHEMBL7928854 | 0.82 | MAOB (0.47) | SMN1; SMN2GSTP1ADORA2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835868-B1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | LILLY CO ELI (US) | 2001-08-29 | — | — | EP | disclosed |
| US-5929090-A | NOVEL COMPOUNDS FOR TREATING ESTROGEN DEPRIVATION CAUSED BY MENOPAUSE OR OVARIECTOMY; TREATING OSTEOPOROSIS, CARDIOVASCULAR DISEASES, AND ENDOMETRIOSIS | ELI LILLY AND COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| EP-0835868-A1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |