Water

Water

SCHEMBL7929515

CCN(CC)CC.[Ca+2].[OH-].[OH-]

nearest known ligand 0.33

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Known targets — ChEMBL curated mechanism

GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.33
HRH3 Q9Y5N1 1/20 0.32
MGLL Q99685 1/20 0.31
CYP2C9 P11712 1/20 0.30
HPGD P15428 1/20 0.30
HSD17B10 Q99714 1/20 0.30
KDM4E B2RXH2 1/20 0.30
MEN1 O00255 1/20 0.30
POLB P06746 1/20 0.30
MAPT P10636 1/20 0.30
THRB P10828 1/20 0.30
APEX1 P27695 1/20 0.30
MAPK1 P28482 1/20 0.30
HTT P42858 1/20 0.30
RECQL P46063 1/20 0.30
CACNA1B Q00975 1/20 0.30
APBA1 Q02410 1/20 0.30
KMT2A Q03164 1/20 0.30
MCL1 Q07820 1/20 0.30
HKDC1 Q2TB90 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL27460512 0.90 ALDH1A1 (0.33) ALDH1A1HRH3MGLLCYP2C9HPGD
Water SCHEMBL3805712 0.90
Water SCHEMBL28135710 0.90 ALDH1A1 (0.33) ALDH1A1HRH3MGLLCYP2C9HPGD
Lithium Ion SCHEMBL2998725 0.90
Hydrochloric Acid SCHEMBL27951711 0.90 ALDH1A1 (0.33) ALDH1A1HRH3MGLLCYP2C9HPGD
SCHEMBL23539383 0.90
Water SCHEMBL29009196 0.90 ALDH1A1 (0.33) ALDH1A1HRH3MGLLCYP2C9HPGD
SCHEMBL9750155 0.90
Potassium Ion SCHEMBL6573907 0.90
Potassium Ion SCHEMBL27574503 0.90 ALDH1A1 (0.33) ALDH1A1HRH3MGLLCYP2C9HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1023259-B1 PROCESS FOR THE OXIDATION OF DI-, TRI-, OLIGO- AND POLYSACCHARIDES INTO POLYHYDROXYCARBOXYLIC ACIDS AKZO NOBEL NV (NL) 2001-11-21 EP disclosed
EP-1023259-A1 PROCESS FOR THE OXIDATION OF DI-, TRI-, OLIGO- AND POLYSACCHARIDES INTO POLYHYDROXYCARBOXYLIC ACIDS Akzo Nobel N.V. (NL) 2000-08-02 EP disclosed
WO-1997034861-A1 PROCESS FOR THE OXIDATION OF DI-, TRI-, OLIGO- AND POLYSACCHARIDES INTO POLYHYDROXYCARBOXYLIC ACIDS AKZO NOBEL N.V. (NL) 1997-09-25 WO disclosed
US-4111910-A POLYCARBONATES HAVING CARBAMATE TERMINAL GROUPS THE DOW CHEMICAL COMPANY (US) 1978-09-05 US disclosed