Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.39 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7216080 | 0.86 | SMN1; SMN2 (0.40) | TDP1L3MBTL1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL6352411 | 0.81 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1LMNACYP3A4KDM4E | |
| SCHEMBL2773644 | 0.81 | CA2 (0.52) | L3MBTL1SMN1; SMN2ALDH1A1MEN1USP2 | |
| SCHEMBL7928439 | 0.80 | TDP1 (0.37) | TDP1L3MBTL1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL1487719 | 0.79 | LPL (0.53) | SMN1; SMN2ALDH1A1MEN1USP2LMNA | |
| SCHEMBL2769520 | 0.78 | ESR1 (0.55) | SMN1; SMN2ALDH1A1MEN1USP2LMNA | |
| SCHEMBL2770828 | 0.78 | ESR1 (0.55) | SMN1; SMN2ALDH1A1MEN1USP2LMNA | |
| SCHEMBL718156 | 0.78 | ESR1 (0.55) | SMN1; SMN2ALDH1A1MEN1USP2LMNA | |
| SCHEMBL20419190 | 0.77 | POLB (0.45) | TDP1L3MBTL1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL7928359 | 0.77 | IDO1 (0.36) | TDP1L3MBTL1SMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140896-A1 | BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 | Takeda Chemical Industries, Ltd. (JP) | 2001-10-10 | — | — | EP | disclosed |
| US-6235771-B1 | AIDS THERPAY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| WO-2000037455-A1 | BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-06-29 | — | — | WO | disclosed |