Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.67 |
| ▸ | RAB9A | P51151 | 4/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.66 |
| ▸ | ALPL | P05186 | 2/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2766145 | 0.83 | RAB9A (0.71) | NPC1RAB9ASMN1; SMN2L3MBTL1ALPL | |
| SCHEMBL24120010 | 0.81 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2L3MBTL1ALPL | |
| SCHEMBL2360295 | 0.80 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2L3MBTL1ALPL | |
| SCHEMBL792992 | 0.80 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2L3MBTL1CYP1A2 | |
| SCHEMBL15908507 | 0.80 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2L3MBTL1ALPL | |
| SCHEMBL14097585 | 0.80 | L3MBTL1 (0.92) | NPC1RAB9ASMN1; SMN2L3MBTL1CYP1A2 | |
| SCHEMBL4116250 | 0.79 | L3MBTL1 (0.65) | NPC1RAB9ASMN1; SMN2L3MBTL1ALK | |
| SCHEMBL427627 | 0.79 | L3MBTL1 (1.00) | NPC1RAB9ASMN1; SMN2L3MBTL1CYP1A2 | |
| SCHEMBL13363876 | 0.78 | CYP1A2 (0.66) | NPC1RAB9ASMN1; SMN2L3MBTL1ALPL | |
| SCHEMBL6263733 | 0.78 | RAB9A (0.61) | NPC1RAB9ASMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170217923-A1 | THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2017-08-03 | — | — | US | disclosed |
| US-9580391-B2 | Saturated acyl guanidine for inhibition of F1F0-ATPase | LYCERA CORPORATION (US) | 2017-02-28 | — | — | US | disclosed |
| EP-3056207-A1 | THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | Otsuka Pharmaceutical Co., Ltd. (JP) | 2016-08-17 | — | — | EP | disclosed |
| EP-2459547-B1 | HERBICIDALLY ACTIVE HETEROARYL-SUBSTITUTED CYCLIC DIONES OR DERIVATIVES THEREOF | SYNGENTA LTD (GB) | 2016-04-20 | — | — | EP | disclosed |
| US-9221814-B2 | Heterocyclic guanidine F1F0-atpase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2015-12-29 | — | — | US | disclosed |
| US-20150307477-A1 | THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | GALENEA CORPORATION | 2015-10-29 | — | — | US | disclosed |
| US-9051300-B2 | Herbicides | SYNGENTA LIMITED (GB) | 2015-06-09 | — | — | US | disclosed |
| US-20150148373-A1 | HETEROCYCLIC GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2015-05-28 | — | — | US | disclosed |
| US-20150119439-A1 | SATURATED ACYL GUANIDINE FOR INHIBITION OF F1F0-ATPASE | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2015-04-30 | — | — | US | disclosed |
| EP-2462139-B1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2015-01-14 | — | — | EP | disclosed |
| US-7230116-B2 | Pyrazolyl-substituted heterocycles and their use as phytosanitary products | BAYER CROPSCIENCE, AG (DE) | 2007-06-12 | — | — | US | disclosed |
| US-7230116-B2 | Pyrazolyl-substituted heterocycles and their use as phytosanitary products | BAYER CROPSCIENCE, AG (DE) | 2007-06-12 | — | — | US | disclosed |
| US-7230116-B2 | Pyrazolyl-substituted heterocycles and their use as phytosanitary products | BAYER CROPSCIENCE, AG (DE) | 2007-06-12 | — | — | US | disclosed |
| EP-1440066-B1 | PYRAZOLYL-SUBSTITUTED HETEROCYCLES AND THEIR USE AS PHYTOSANITARY PRODUCTS | BAYER CROPSCIENCE AG (DE) | 2007-03-07 | — | — | EP | disclosed |
| EP-1440066-B1 | PYRAZOLYL-SUBSTITUTED HETEROCYCLES AND THEIR USE AS PHYTOSANITARY PRODUCTS | BAYER CROPSCIENCE AG (DE) | 2007-03-07 | — | — | EP | disclosed |
| CN-1630653-A | Pyrazolyl-substituted heterocycles and their use as pest control agents | BAYER CROPSCIENCE AG (DE) | 2005-06-22 | — | — | CN | disclosed |
| US-20040242664-A1 | Pyrazolyl-substituted heterocycles and their use as phytosanitary products | BAYER CROPSCIENCE AG (DE) | 2004-12-02 | — | — | US | disclosed |
| EP-1440066-A1 | PYRAZOLYL-SUBSTITUTED HETEROCYCLES AND THEIR USE AS PHYTOSANITARY PRODUCTS | Bayer CropScience AG (DE) | 2004-07-28 | — | — | EP | disclosed |
| WO-2003035643-A1 | PYRAZOLYL-SUBSTITUTED HETEROCYCLES AND THEIR USE AS PHYTOSANITARY PRODUCTS | BAYER CROPSCIENCE AG (DE) | 2003-05-01 | — | — | WO | disclosed |
| EP-0945437-A1 | Pyrazolyl acrylic acid- and pyrazolyl oximino-acetic acid derivatives, their preparation and their use as fungicides | SDS Biotech K.K. (JP) | 1999-09-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150148373-A1 | HETEROCYCLIC GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | ATP5F1A, ATP5ME, ATP5F1D | NPC1 1827/4885RAB9A 448/4885SMN1; SMN2 3278/4885 |
| US-20150307477-A1 | THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | PPP4C, PTPRG, PPP2CA | NPC1 2700/4885RAB9A 1231/4885SMN1; SMN2 3273/4885 |
| US-20040242664-A1 | Pyrazolyl-substituted heterocycles and their use as phytosanitary products | CYP1A1, CYP1B1, CYP8B1 | NPC1 3628/4885RAB9A 2000/4885SMN1; SMN2 4620/4885 |
| US-20150119439-A1 | SATURATED ACYL GUANIDINE FOR INHIBITION OF F1F0-ATPASE | ATP5F1A, ATP5F1D, ATP5F1C | NPC1 627/4885RAB9A 720/4885SMN1; SMN2 2421/4885 |
| US-20170217923-A1 | THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | PPP4C, PTPRG, PPP2CA | NPC1 2700/4885RAB9A 1231/4885SMN1; SMN2 3273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.