SCHEMBL7930236

SCHEMBL7930236

CCC(=O)c1ccccc1-c1ccccc1C(C)(C)C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 1/20 0.44
KMT2A Q03164 2/20 0.39
MEN1 O00255 1/20 0.39
ALDH1A1 P00352 4/20 0.38
TSHR P16473 2/20 0.38
TDP1 Q9NUW8 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
MAPT P10636 1/20 0.37
HSP90AB1 P08238 1/20 0.36
ELANE P08246 1/20 0.36
PRTN3 P24158 1/20 0.36
CA2 P00918 1/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
KDM4E B2RXH2 2/20 0.34
GAA P10253 1/20 0.34
RXRA P19793 1/20 0.34
RXRB P28702 1/20 0.34
RXRG P48443 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11297486 0.85 ALDH1A1 (0.43) PDK2KMT2AALDH1A1TSHRTDP1
SCHEMBL5666601 0.79 TSHR (0.61) PDK2KMT2AMEN1ALDH1A1TSHR
SCHEMBL13451780 0.78 PDK2 (0.45) PDK2KMT2AMEN1ALDH1A1TSHR
SCHEMBL28738497 0.78 MYC (0.52) PDK2KMT2AMEN1ALDH1A1TDP1
SCHEMBL28172418 0.78 CTSD (0.47) KMT2AMEN1ALDH1A1TDP1L3MBTL1
SCHEMBL27645716 0.77 CA2 (0.55) PDK2ALDH1A1TSHRTDP1HSP90AB1
SCHEMBL6518446 0.77 CDK4 (0.46) PDK2KMT2AMEN1ALDH1A1SMN1; SMN2
SCHEMBL9538711 0.77 HSP90AB1 (0.47) PDK2KMT2AMEN1ALDH1A1TSHR
SCHEMBL28523326 0.77 PDK2 (0.41) PDK2KMT2AMEN1ALDH1A1TSHR
SCHEMBL28116443 0.77 PDK2 (0.44) PDK2KMT2AMEN1TSHRSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1097158-A2 LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2001-05-09 EP disclosed
WO-2000002887-A2 LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2000-01-20 WO disclosed