Phosphoric Acid

Phosphoric Acid

SCHEMBL7930393

NC(=O)c1c[nH]cc1C(N)=O.O=P(O)(O)O.O=P(O)(O)O.O=P(O)(O)O

nearest known ligand 0.38

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Known targets — ChEMBL curated mechanism

ADRA1AADRA1BADRA1DADRB1ADRB2ADRB3CYP11B1DPP4FGFR1FGFR2FGFR3FGFR4HRH1JAK1JAK2JAK3KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITNAOPRD1OPRK1OPRM1PPDGFRBPIK3CDSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASMOTYK2polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FGFR1 known ✓ P11362 1/20 0.31
KDR known ✓ P35968 1/20 0.31
ALDH1A1 P00352 4/20 0.38
ATM Q13315 2/20 0.38
MAPT P10636 2/20 0.36
NOTUM Q6P988 1/20 0.36
KDM4E B2RXH2 1/20 0.36
HPGD P15428 1/20 0.36
TSHR P16473 1/20 0.36
HSD17B10 Q99714 1/20 0.36
KMT2A Q03164 3/20 0.33
MEN1 O00255 1/20 0.33
MAPK1 P28482 1/20 0.33
CAPN1 P07384 1/20 0.33
METAP2 P50579 1/20 0.33
PDPK1 O15530 1/20 0.32
BCAT2 O15382 1/20 0.32
CA4 P22748 1/20 0.31
PLK4 O00444 1/20 0.31
CHEK1 O14757 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7705143 0.89 ALDH1A1 (0.43) ALDH1A1ATMMAPTNOTUMKDM4E
Phosphoric Acid SCHEMBL31026558 0.74 ALDH1A1 (0.58) ALDH1A1ATMMAPTKDM4EHPGD
Phosphoric Acid SCHEMBL29057869 0.74 ALDH1A1 (0.58) ALDH1A1ATMMAPTKDM4EHPGD
SCHEMBL826686 0.72
SCHEMBL24638465 0.67 CDC7 (0.36) ALDH1A1ATMMAPTNOTUMKDM4E
Phosphoric Acid SCHEMBL4147807 0.65 LMNA (0.60) ALDH1A1KDM4EHPGDTSHRHSD17B10
Phosphoric Acid SCHEMBL10706626 0.65 LMNA (0.60) ALDH1A1KDM4EHPGDTSHRHSD17B10
Phosphoric Acid SCHEMBL7079957 0.65 LMNA (0.60) ALDH1A1KDM4EHPGDTSHRHSD17B10
Phosphoric Acid SCHEMBL11042049 0.65 LMNA (0.60) ALDH1A1KDM4EHPGDTSHRHSD17B10
Phosphoric Acid SCHEMBL28117697 0.65 LMNA (0.60) ALDH1A1KDM4EHPGDTSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6239159-B1 SUBSTRATES FOR POLYMERASE AND TERMINAL TRANSFERASE ENZYMES. CAPABLE OF BASE-PAIRING WITH A NUCLEOTIDE RESIDUE IN A COMPLEMENTARY CHAIN OR BASE STACKING IN THE APPROPRIATE NUCLEIC ACID CHAIN, ADVANTAGE OVER CONVENTIONAL HAPTEN AMERSHAM PHARMACIA BIOTECH UK LIMITED (GB) 2001-05-29 US disclosed
EP-0885235-A1 NUCLEOSIDE ANALOGUES Amersham Pharmacia Biotech UK Limited (GB) 1998-12-23 EP disclosed
WO-1997028176-A1 NUCLEOSIDE ANALOGUES AMERSHAM PHARMACIA BIOTECH UK LIMITED (GB) 1997-08-07 WO disclosed