Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7495961 | 1.00 | LMNA (0.49) | LMNAGAACCR5KDM4ECYP2D6 | |
| SCHEMBL7497904 | 0.83 | MEN1 (0.36) | CCR5KDM4EALDH1A1CYP2C19MEN1 | |
| SCHEMBL7986574 | 0.83 | MEN1 (0.36) | CCR5KDM4EALDH1A1CYP2C19MEN1 | |
| SCHEMBL7972727 | 0.83 | MEN1 (0.36) | CCR5KDM4EALDH1A1CYP2C19MEN1 | |
| SCHEMBL7986474 | 0.81 | HRH3 (0.44) | CCR5HRH3KCNH2 | |
| SCHEMBL7497446 | 0.81 | HRH3 (0.44) | CCR5HRH3KCNH2 | |
| SCHEMBL7986475 | 0.81 | HRH3 (0.44) | CCR5HRH3KCNH2 | |
| SCHEMBL7492543 | 0.81 | CYP2C9 (0.36) | CCR5CYP2D6ALDH1A1CYP2C19 | |
| SCHEMBL7986267 | 0.81 | CYP2C9 (0.36) | CCR5CYP2D6ALDH1A1CYP2C19 | |
| SCHEMBL7940918 | 0.79 | CCR5 (0.48) | CCR5HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248755-B1 | ANTIINFLAMMATORY AGENTS; ANTIALLERGENS; AUTOIMMUNE DISEASES | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |