Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 9/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.34 |
| ▸ | CMA1 | P23946 | 1/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7492543 | 1.00 | CYP2C9 (0.36) | CYP2C9HPGDCYP2C19HTTCASR | |
| SCHEMBL7986574 | 0.83 | MEN1 (0.36) | CYP2C9CYP2C19HTTALDH1A1CCR5 | |
| SCHEMBL7972727 | 0.83 | MEN1 (0.36) | CYP2C9CYP2C19HTTALDH1A1CCR5 | |
| SCHEMBL7497904 | 0.83 | MEN1 (0.36) | CYP2C9CYP2C19HTTALDH1A1CCR5 | |
| SCHEMBL7495961 | 0.81 | LMNA (0.49) | CYP2C19ALDH1A1CCR5CYP2D6 | |
| SCHEMBL7931908 | 0.81 | LMNA (0.49) | CYP2C19ALDH1A1CCR5CYP2D6 | |
| SCHEMBL7986474 | 0.74 | HRH3 (0.44) | HTTCCR5 | |
| SCHEMBL7986475 | 0.74 | HRH3 (0.44) | HTTCCR5 | |
| SCHEMBL7497446 | 0.74 | HRH3 (0.44) | HTTCCR5 | |
| SCHEMBL7817932 | 0.73 | CCR5 (0.57) | HTTALDH1A1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265434-B1 | ANTIINFLAMMATORY AGENTS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |