SCHEMBL7932433

SCHEMBL7932433

O=C1NC(=O)c2cc(C(F)(F)F)c(C(F)(F)F)cc21

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES1 P23141 1/20 0.42
PPOX P50336 1/20 0.41
GSK3B P49841 1/20 0.40
TDP2 O95551 2/20 0.39
TDP1 Q9NUW8 3/20 0.38
PRKD3 O94806 3/20 0.38
EGFR P00533 3/20 0.38
PRKCG P05129 3/20 0.38
PRKCB P05771 3/20 0.38
SRC P12931 3/20 0.38
PRKCA P17252 3/20 0.38
PRKCH P24723 3/20 0.38
PRKCI P41743 3/20 0.38
PRKCE Q02156 3/20 0.38
PRKCQ Q04759 3/20 0.38
PRKCZ Q05513 3/20 0.38
PRKCD Q05655 3/20 0.38
PRKD1 Q15139 3/20 0.38
MEN1 O00255 2/20 0.38
MAPT P10636 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3884186 0.85 CES1 (0.37) CES1PPOXGSK3BTDP2TDP1
SCHEMBL3871129 0.85 CES1 (0.37) CES1PPOXGSK3BTDP2TDP1
SCHEMBL10836481 0.79 CA2 (0.54) CES1PPOXGSK3BMEN1KMT2A
SCHEMBL22070109 0.75 ALOX15 (0.42) CES1TDP1CYP3A4POLBALDH1A1
SCHEMBL2733540 0.75 STK10 (0.35) CES1PPOXGSK3BTDP2TDP1
SCHEMBL31586640 0.73 TDP2 (0.59) PPOXGSK3BTDP2TDP1MEN1
SCHEMBL5194204 0.73 TDP2 (0.59) PPOXGSK3BTDP2TDP1MEN1
SCHEMBL1081926 0.73 GRM5 (0.55) PPOXGSK3BTDP1PRKD3EGFR
SCHEMBL8834408 0.72 EGFR (0.56) CES1TDP1PRKD3EGFRPRKCG
SCHEMBL9839461 0.72 CDC25B (0.41) CES1POLBGLAMAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6191307-B1 Process for making benzoic acids ALBEMARLE CORPORATION 2001-02-20 US disclosed