Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7935461 | 0.83 | HTR6 (0.32) | SIGMAR1HTR6HTR2A | |
| Hydrochloric Acid SCHEMBL4479585 | 0.83 | RET (0.38) | SIGMAR1MEN1KMT2AHTR6HTR2A | |
| Hydrochloric Acid SCHEMBL6917972 | 0.70 | SIGMAR1 (0.33) | SIGMAR1HTR6HTR2A | |
| Hydrochloric Acid SCHEMBL215793 | 0.70 | HTR2A (0.36) | SIGMAR1HTR6HTR2A | |
| Hydrochloric Acid SCHEMBL7951350 | 0.70 | HTR2A (0.36) | SIGMAR1HTR6HTR2A | |
| Hydrochloric Acid SCHEMBL964733 | 0.69 | HTR2A (0.37) | SIGMAR1MEN1KMT2AHTR6HTR2A | |
| Hydrochloric Acid SCHEMBL15283336 | 0.69 | HTR2A (0.37) | SIGMAR1MEN1KMT2AHTR6HTR2A | |
| Hydrochloric Acid SCHEMBL1538529 | 0.69 | HTR2A (0.37) | SIGMAR1MEN1KMT2AHTR6HTR2A | |
| Hydrochloric Acid SCHEMBL29556619 | 0.69 | HTR2A (0.33) | SIGMAR1MEN1KMT2AHTR6HTR2A | |
| Hydrochloric Acid SCHEMBL216949 | 0.69 | HTR2A (0.33) | SIGMAR1MEN1KMT2AHTR6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184402-B1 | RESOLUTION OF A STEREOISOMERIC MIXTURE OF SPECIFIC METALLOCENE COMPLEXES BRIDGED WITH A TRANSITION METAL HAVING AN OXYGEN BOND ATTACHED, I.E., A MU-OXO COMPLEX; HYDROLYSIS IN THE PRESENCE OF A BASE; SEPARATION OF MESO FORM FROM MIXES | CHISSO CORPORATION (JP) | 2001-02-06 | — | — | US | disclosed |