Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7933148 | 0.83 | SIGMAR1 (0.31) | HTR6HTR2ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL4479585 | 0.79 | RET (0.38) | HTR6HTR2ASIGMAR1CYP3A4SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6917972 | 0.72 | SIGMAR1 (0.33) | HTR6HTR2ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL215793 | 0.72 | HTR2A (0.36) | HTR6HTR2ASIGMAR1CYP3A4 | |
| Hydrochloric Acid SCHEMBL7951350 | 0.72 | HTR2A (0.36) | HTR6HTR2ASIGMAR1CYP3A4 | |
| Hydrochloric Acid SCHEMBL217385 | 0.69 | HTR6 (0.32) | HTR6HTR2ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL4477740 | 0.69 | HTR6 (0.32) | HTR6HTR2ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL7939816 | 0.69 | HTR6 (0.32) | HTR6HTR2ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL7943861 | 0.69 | HTR6 (0.32) | HTR6HTR2ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL7944168 | 0.69 | ATM (0.34) | HTR6HTR2ASIGMAR1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184402-B1 | RESOLUTION OF A STEREOISOMERIC MIXTURE OF SPECIFIC METALLOCENE COMPLEXES BRIDGED WITH A TRANSITION METAL HAVING AN OXYGEN BOND ATTACHED, I.E., A MU-OXO COMPLEX; HYDROLYSIS IN THE PRESENCE OF A BASE; SEPARATION OF MESO FORM FROM MIXES | CHISSO CORPORATION (JP) | 2001-02-06 | — | — | US | disclosed |