SCHEMBL7933393

SCHEMBL7933393

CO/C=C(\C(=O)O)c1ccc(Cl)cc1F

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CXCL12 P48061 1/20 0.44
CYP11B2 P19099 4/20 0.44
CYP11B1 P15538 3/20 0.44
PPARG P37231 2/20 0.40
PPARA Q07869 2/20 0.40
ALDH1A1 P00352 2/20 0.40
ABL1 P00519 1/20 0.40
TSHR P16473 1/20 0.39
CASP1 P29466 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
MAOB P27338 2/20 0.38
MAOA P21397 1/20 0.38
SLC6A4 P31645 1/20 0.37
HTT P42858 1/20 0.37
GPR27 Q9NS67 1/20 0.36
MAPT P10636 1/20 0.36
RAB9A P51151 1/20 0.36
GRIK1 P39086 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7944695 0.84 TSHR (0.53) CXCL12ALDH1A1ABL1TSHRCASP1
SCHEMBL7942220 0.84 CES2 (0.50) CYP11B2CYP11B1
SCHEMBL7933394 0.84 CYP11B2 (0.45) CXCL12CYP11B2CYP11B1PPARGPPARA
SCHEMBL7168867 0.74 AKR1C3 (0.50) ALDH1A1TSHRSMN1; SMN2MAOBMAOA
SCHEMBL8958972 0.74 AKR1C3 (0.50) ALDH1A1TSHRSMN1; SMN2MAOBMAOA
SCHEMBL1350185 0.74 ABL1 (0.64) CXCL12CYP11B2CYP11B1ALDH1A1ABL1
SCHEMBL7168869 0.74 AKR1C3 (0.50) ALDH1A1TSHRSMN1; SMN2MAOBMAOA
SCHEMBL7840274 0.73 CES2 (0.50) CYP11B2CYP11B1PPARGPPARAALDH1A1
SCHEMBL392840 0.73 SMN1; SMN2 (0.63) CYP11B2ALDH1A1TSHRCASP1SMN1; SMN2
SCHEMBL1339680 0.72 CYP11B1 (0.56) CXCL12CYP11B2CYP11B1ALDH1A1ABL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6242634-B1 OF HERBICIDES, HALOPHENYL COMPOUNDS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-06-05 US disclosed
US-6100257-A 2-HALOALKYL,3-(HALOALKYL, ALKENYL, OR ALKYNYL),5-(SUBSTITUTED PHENYL OR HETEROCYCLE),6-ALKYL-PYRIMIDIN-4-ONE COMPOUNDS OF GIVEN STRUCTURE; USE AS HERBICIDES SUMITOMO CHEMICAL COMPANY, LTD. (JP) 2000-08-08 US disclosed
EP-0850229-A1 PYRIMIDIN-4-ONE DERIVATIVES, THEIR USE AS HERBICIDES, INTERMEDIATES FOR THEIR PRODUCTION AND PROCESSES FOR PRODUCING THESE COMPOUNDS SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1998-07-01 EP disclosed
WO-1997006150-A1 PYRIMIDIN-4-ONE DERIVATIVES, THEIR USE AS HERBICIDES, INTERMEDIATES FOR THEIR PRODUCTION AND PROCESSES FOR PRODUCING THESE COMPOUNDS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-02-20 WO disclosed