Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Benzylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | ANPEP | P15144 | 4/20 | 0.52 |
| ▸ | LAP3 | P28838 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.48 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.48 |
| ▸ | FDPS | P14324 | 1/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzylamine SCHEMBL28106183 | 1.00 | LOXL2 (0.70) | LOXL2TSHRCYP2C19CYP1A2CYP2D6 | |
| Benzylamine SCHEMBL8108778 | 1.00 | LOXL2 (0.70) | LOXL2TSHRCYP2C19CYP1A2CYP2D6 | |
| Benzylamine SCHEMBL5685880 | 0.91 | LOXL2 (0.64) | LOXL2TSHRCYP2C19CYP1A2CYP2D6 | |
| Medronic Acid SCHEMBL11771504 | 0.89 | LOXL2 (0.61) | LOXL2TSHRCYP2C19CYP1A2CYP2D6 | |
| Phosphoric Acid SCHEMBL29157454 | 0.88 | ENPP2 (0.58) | LOXL2TSHRCYP2C19CYP1A2CYP2D6 | |
| Benzylamine SCHEMBL27781209 | 0.87 | LOXL2 (0.93) | LOXL2TSHRCYP2C19CYP1A2CYP2D6 | |
| Phenol SCHEMBL1458667 | 0.86 | ENPP2 (0.62) | LOXL2TSHRCYP2C19CYP1A2CYP2D6 | |
| Phosphoric Acid SCHEMBL29157451 | 0.86 | ENPP2 (0.56) | LOXL2TSHRCYP2C19CYP1A2CYP2D6 | |
| Benzylamine SCHEMBL2841167 | 0.84 | LOXL2 (0.78) | LOXL2TSHRCYP2C19CYP1A2CYP2D6 | |
| Benzylamine SCHEMBL2841170 | 0.84 | LOXL2 (0.78) | LOXL2TSHRCYP2C19CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174485-A | Cleaning agent and cleaning agent with improved enzyme stability | 汉高股份有限及两合公司 | 2022-03-11 | — | — | CN | claimed |
| CN-106316966-A | Preparation method of medical intermediate N-(2-methylpyrazine)benzylamine phosphate compound | 董运勤 | 2017-01-11 | — | — | CN | claimed |
| CN-100361978-C | 2-pyrimidine oxy-N-aryl 7-nitrile or organic phosphate benzylamine compound, its production and use thereof | SHANGHAI INST ORGANIC CHEM (CN) | 2008-01-16 | — | — | CN | claimed |
| CN-1746161-A | 2-2-pyrimidinyl oxy-N-aryl-7-itrile group or organic phosphate benzylamine compound, preparation method and its usage | SHANGHAI INST ORGANIC CHEM (CN) | 2006-03-15 | — | — | CN | claimed |
| EP-0436301-B1 | Crystal-polymer matrix composites | BRITISH TECH GROUP (GB) | 1995-03-15 | — | — | EP | claimed |
| US-5167888-A | In situ growth of organic and/or inorganic crystals in a polymer matrix by using temperature gradient zone melting technique | THE BRITISH PETROLEUM COMPANY P.L.C. (GB) | 1992-12-01 | — | — | US | claimed |
| EP-0436301-A2 | Crystal-polymer matrix composites | BTG INTERNATIONAL LIMITED (GB) | 1991-07-10 | — | — | EP | claimed |
| CN-114174485-A | Cleaning agent and cleaning agent with improved enzyme stability | 汉高股份有限及两合公司 | 2022-03-11 | — | — | CN | disclosed |
| CN-106316966-A | Preparation method of medical intermediate N-(2-methylpyrazine)benzylamine phosphate compound | 董运勤 | 2017-01-11 | — | — | CN | disclosed |
| CN-100361978-C | 2-pyrimidine oxy-N-aryl 7-nitrile or organic phosphate benzylamine compound, its production and use thereof | SHANGHAI INST ORGANIC CHEM (CN) | 2008-01-16 | — | — | CN | disclosed |
| CN-100361978-C | 2-pyrimidine oxy-N-aryl 7-nitrile or organic phosphate benzylamine compound, its production and use thereof | SHANGHAI INST ORGANIC CHEM (CN) | 2008-01-16 | — | — | CN | disclosed |
| CN-1746161-A | 2-2-pyrimidinyl oxy-N-aryl-7-itrile group or organic phosphate benzylamine compound, preparation method and its usage | SHANGHAI INST ORGANIC CHEM (CN) | 2006-03-15 | — | — | CN | disclosed |
| CN-1746161-A | 2-2-pyrimidinyl oxy-N-aryl-7-itrile group or organic phosphate benzylamine compound, preparation method and its usage | SHANGHAI INST ORGANIC CHEM (CN) | 2006-03-15 | — | — | CN | disclosed |
| WO-2001017992-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |
| EP-1012134-A1 | QUATERNARY AMMONIUM PHOSPHATE COMPOUNDS AND METHOD OF PREPARING THE SAME | SK Chemicals (KR) | 2000-06-28 | — | — | EP | disclosed |
| WO-1999012889-A1 | QUATERNARY AMMONIUM PHOSPHATE COMPOUND AND METHOD OF PREPARING THE SAME | SK CHEMICALS (KR) | 1999-03-18 | — | — | WO | disclosed |
| EP-0436301-B1 | Crystal-polymer matrix composites | BRITISH TECH GROUP (GB) | 1995-03-15 | — | — | EP | disclosed |
| US-5190822-A | Drug delivery, stability | FUJI PHOTO FILM CO., LTD. (JP) | 1993-03-02 | — | — | US | disclosed |
| US-5167888-A | In situ growth of organic and/or inorganic crystals in a polymer matrix by using temperature gradient zone melting technique | THE BRITISH PETROLEUM COMPANY P.L.C. (GB) | 1992-12-01 | — | — | US | disclosed |
| EP-0436301-A2 | Crystal-polymer matrix composites | BTG INTERNATIONAL LIMITED (GB) | 1991-07-10 | — | — | EP | disclosed |