Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1001083 | 0.80 | PIK3CD (0.39) | RETTACR3HCRTR2S1PR1S1PR3 | |
| SCHEMBL28802685 | 0.77 | S1PR1 (0.36) | RETTACR3HCRTR2S1PR1S1PR3 | |
| SCHEMBL1004185 | 0.77 | MAPK1 (0.44) | HCRTR2S1PR1S1PR3GSK3BDYRK1A | |
| SCHEMBL4575792 | 0.74 | RAB9A (0.45) | RETHCRTR2S1PR1S1PR3ENPP3 | |
| SCHEMBL13662711 | 0.74 | LTA4H (0.46) | ENPP3ENPP1MTORPIK3CAELANE | |
| SCHEMBL4574780 | 0.74 | S1PR1 (0.39) | RETTACR3HCRTR2S1PR1S1PR3 | |
| SCHEMBL19399205 | 0.74 | HCRTR2 (0.48) | RETHCRTR2S1PR1S1PR3ENPP3 | |
| SCHEMBL27886547 | 0.73 | HDAC1 (0.37) | RETHCRTR2S1PR1S1PR3NOTUM | |
| SCHEMBL2566347 | 0.72 | FAAH (0.53) | MTORPIK3CAKCNH2 | |
| SCHEMBL1002558 | 0.72 | MAPK1 (0.43) | GSK3BDYRK1AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010017079-A1 | OXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK & CO., INC. (US) | 2010-02-11 | — | — | WO | disclosed |