Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.53 |
| ▸ | MTOR | P42345 | 12/20 | 0.50 |
| ▸ | RPTOR | Q8N122 | 7/20 | 0.50 |
| ▸ | MLST8 | Q9BVC4 | 7/20 | 0.50 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.50 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.48 |
| ▸ | CSF1R | P07333 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 7/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7716252 | 0.78 | FAAH (0.68) | FAAHMTORRPTORMLST8RICTOR | |
| SCHEMBL2562390 | 0.77 | FAAH (0.64) | FAAHMTORRPTORMLST8RICTOR | |
| SCHEMBL7934455 | 0.72 | RET (0.37) | MTORPIK3CAKCNH2 | |
| SCHEMBL1000994 | 0.70 | FAAH (0.48) | FAAHMTORRPTORMLST8RICTOR | |
| SCHEMBL1001299 | 0.70 | FAAH (0.46) | FAAHMTORRPTORMLST8RICTOR | |
| SCHEMBL14574833 | 0.70 | FAAH (0.68) | FAAHMTORRPTORMLST8RICTOR | |
| SCHEMBL14574600 | 0.70 | FAAH (0.68) | FAAHMTORPIK3CASYKKCNH2 | |
| SCHEMBL14574615 | 0.70 | FAAH (0.80) | FAAHKCNH2 | |
| SCHEMBL7715793 | 0.70 | FAAH (1.00) | FAAHKCNH2 | |
| SCHEMBL7710905 | 0.69 | FAAH (0.70) | FAAHKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2555772-B1 | OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME (US) | 2017-01-11 | — | — | EP | disclosed |
| EP-2555772-B1 | OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME (US) | 2017-01-11 | — | — | EP | disclosed |
| US-9193697-B2 | Oxazole derivatives useful as modulators of FAAH | MERCK SHARP & DOHME CORP. (US) | 2015-11-24 | — | — | US | disclosed |
| US-9193697-B2 | Oxazole derivatives useful as modulators of FAAH | MERCK SHARP & DOHME CORP. (US) | 2015-11-24 | — | — | US | disclosed |
| US-9193697-B2 | Oxazole derivatives useful as modulators of FAAH | MERCK SHARP & DOHME CORP. (US) | 2015-11-24 | — | — | US | disclosed |
| EP-2555772-A1 | OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | Merck Sharp & Dohme Corp. (US) | 2013-02-13 | — | — | EP | disclosed |
| US-20130018048-A1 | OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME CORP. (US) | 2013-01-17 | — | — | US | disclosed |
| US-20130018048-A1 | OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME CORP. (US) | 2013-01-17 | — | — | US | disclosed |
| US-20130018048-A1 | OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME CORP. (US) | 2013-01-17 | — | — | US | disclosed |
| WO-2011126960-A1 | OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME CORP. (US) | 2011-10-13 | — | — | WO | disclosed |
| WO-2011126960-A1 | OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME CORP. (US) | 2011-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018048-A1 | OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | FAAH, FAAH2, ALOX5 | FAAH 1/4885MTOR 1942/4885RPTOR 2181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.