Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL455000 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL7945309 | 0.84 | NSD2 (0.32) | NSD2ALDH1A1EGFRLMNAMAPT | |
| Hydrochloric Acid SCHEMBL7716249 | 0.84 | NSD2 (0.31) | NSD2ALDH1A1EGFRLMNAMAPT | |
| Hydrochloric Acid SCHEMBL8823197 | 0.83 | NR3C1 (0.38) | ALDH1A1LMNAMAPT | |
| Fluoride Ion SCHEMBL7635122 | 0.83 | — | — | |
| Hydrochloric Acid SCHEMBL7942050 | 0.81 | ALDH1A1 (0.30) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7945479 | 0.79 | GPR3 (0.30) | — | |
| Hydrochloric Acid SCHEMBL17743504 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL8823193 | 0.75 | GAA (0.33) | ALDH1A1LMNAMAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL452344 | 0.74 | TSHR (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316558-B1 | POLYMERIZING OLEFIN USING CATALYST COMPRISING TRANSITION METAL COMPOUND, COMPOUND CAPABLE OF A REACTING WITH TRANSITION METAL COMPOUND TO FORM A CATIONIC TRANSITION METAL COMPOUND, ORGANOMETALLIC TO FORM POLYOLEFIN | TOSOH CORPORATION (JP) | 2001-11-13 | — | — | US | disclosed |
| EP-0786466-A1 | Transition metal compound, olefin polymerization catalyst comprising the compound, and process for production of olefin polymer | Tosoh Corporation (JP) | 1997-07-30 | — | — | EP | disclosed |