Hydantoin

Hydantoin

SCHEMBL7934632

O=C1CCC(OCc2ccccc2)CC1.O=C1CNC(=O)N1

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OPRM1 P35372 2/20 0.45
OPRL1 P41146 2/20 0.45
DPP4 P27487 1/20 0.42
SIGMAR1 Q99720 2/20 0.41
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
PSEN1 P49768 1/20 0.38
PSEN2 P49810 1/20 0.38
APH1B Q8WW43 1/20 0.38
NCSTN Q92542 1/20 0.38
APH1A Q96BI3 1/20 0.38
PSENEN Q9NZ42 1/20 0.38
TMEM97 Q5BJF2 1/20 0.38
CARM1 Q86X55 1/20 0.38
PRMT6 Q96LA8 1/20 0.38
PRMT8 Q9NR22 1/20 0.38
HRH3 Q9Y5N1 1/20 0.38
EPHX2 P34913 1/20 0.37
HDAC8 Q9BY41 2/20 0.37
CTSL P07711 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL416422 0.84 OPRM1 (0.50) OPRM1OPRL1DPP4SIGMAR1MEN1
Ethylene SCHEMBL7936439 0.81 OPRM1 (0.48) OPRM1OPRL1DPP4SIGMAR1MEN1
SCHEMBL420469 0.79 PSEN1 (0.50) OPRM1OPRL1DPP4SIGMAR1MEN1
SCHEMBL7753890 0.76 ESR2 (0.47) OPRM1OPRL1DPP4SIGMAR1MEN1
SCHEMBL27209463 0.76 SLC6A2 (0.44) OPRM1OPRL1DPP4SIGMAR1MEN1
SCHEMBL1288390 0.75 CYP3A4 (0.47) OPRM1OPRL1DPP4SIGMAR1MEN1
SCHEMBL7985833 0.75 CYP3A4 (0.47) OPRM1OPRL1DPP4SIGMAR1MEN1
Hydantoin SCHEMBL15004947 0.74 LMNA (0.45) HDAC8CTSLCTSBCTSKHTT
Hydrochloric Acid SCHEMBL5722088 0.73 DPP4 (0.56) OPRM1OPRL1DPP4SIGMAR1MEN1
Benzyl Alcohol SCHEMBL18894571 0.72 TSHR (0.52) MEN1KMT2AEPHX2HDAC8DDB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0862464-A4 AMINO ACID ANALOGS FOR TUMOR IMAGING UNIV EMORY (US) 2001-07-25 EP disclosed
US-5817776-A TECHNETIUM 99 COMPLEXES, SINGLE PHOTON EMISSION TOMOGRAPHY EMORY UNIVERSITY (US) 1998-10-06 US disclosed
US-5808146-A Amino acid analogs for tumor imaging EMORY UNIVERSITY (US) 1998-09-15 US disclosed
EP-0862464-A1 AMINO ACID ANALOGS FOR TUMOR IMAGING EMORY UNIVERSITY (US) 1998-09-09 EP disclosed
WO-1997017092-A1 AMINO ACID ANALOGS FOR TUMOR IMAGING EMORY UNIVERSITY (US) 1997-05-15 WO disclosed