Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.38 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.33 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.33 |
| ▸ | OTC | P00480 | 1/20 | 0.32 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.31 |
| ▸ | NPY1R | P25929 | 1/20 | 0.30 |
| ▸ | NPY4R | P50391 | 1/20 | 0.30 |
| ▸ | TLR2 | O60603 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6535302 | 0.92 | GSR (0.45) | GSRGNAI3GNAO1GNAI1OTC | |
| Lysine SCHEMBL16762309 | 0.86 | GSR (0.38) | GSRGNAI3GNAO1GNAI1OTC | |
| Arginine SCHEMBL1278093 | 0.85 | GSR (0.43) | GSRGNAI3GNAO1GNAI1OTC | |
| Arginine SCHEMBL3520968 | 0.84 | GSR (0.33) | GSR | |
| SCHEMBL2899157 | 0.82 | OTC (0.43) | GSROTCDDAH1NPY1RNPY4R | |
| SCHEMBL301607 | 0.82 | GNAI3 (0.46) | GSRGNAI3GNAO1GNAI1OTC | |
| SCHEMBL11660913 | 0.82 | GNAI3 (0.46) | GSRGNAI3GNAO1GNAI1OTC | |
| Arginine SCHEMBL18149039 | 0.81 | GSR (0.59) | GSRGNAI3GNAO1GNAI1OTC | |
| Arginine SCHEMBL19181970 | 0.81 | GSR (0.59) | GSRGNAI3GNAO1GNAI1OTC | |
| Arginine SCHEMBL22207237 | 0.81 | GSR (0.59) | GSRGNAI3GNAO1GNAI1OTC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262017-B1 | CONTAINING A CELL ADHESION-RELATED AMINO ACID SEQUENCE, AND TO DEVICES AND BIOMATERIALS FOR IMPLANTATION COATED WITH OR INCORPORATING PEPTIDES CONTAINING THAT SEQUENCE. | RESEARCH CORPORATION TECHNOLOGIES, INC. | 2001-07-17 | — | — | US | disclosed |