Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.43 |
| ▸ | DDAH1 | O94760 | 4/20 | 0.41 |
| ▸ | NOS2 | P35228 | 5/20 | 0.39 |
| ▸ | NOS3 | P29474 | 4/20 | 0.39 |
| ▸ | NOS1 | P29475 | 4/20 | 0.39 |
| ▸ | GSR | P00390 | 1/20 | 0.36 |
| ▸ | NPY4R | P50391 | 3/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.34 |
| ▸ | ARG1 | P05089 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL26980027 | 0.92 | GSR (0.46) | OTCDDAH1NOS2NOS3NOS1 | |
| SCHEMBL6535302 | 0.90 | GSR (0.45) | OTCDDAH1NOS2NOS3NOS1 | |
| SCHEMBL18877225 | 0.86 | NPY4R (0.36) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL1790 | 0.85 | OTC (0.56) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL288132 | 0.85 | OTC (0.56) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL29518651 | 0.85 | OTC (0.56) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL6374054 | 0.85 | OTC (0.56) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL7928810 | 0.85 | OTC (0.56) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL2411547 | 0.85 | OTC (0.56) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL1791 | 0.85 | OTC (0.56) | OTCDDAH1NOS2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 130 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210251963-A1 | UREA DERIVATIVES FOR USE IN THE TREATMENT OF SUBJECTS WITH ELEVATED EXPRESSION AND/OR ACTIVITY OF SRPK1 | SCANDION ONCOLOGY A/S (DK) | 2021-08-19 | — | — | US | claimed |
| EP-3846802-A1 | UREA DERIVATIVES FOR USE IN THE TREATMENT OF SUBJECTS WITH ELEVATED EXPRESSION AND/OR ACTIVITY OF SRPK1 | Scandion Oncology A/S (DK) | 2021-07-14 | — | — | EP | claimed |
| US-8475792-B2 | Molecules with extended half-lives, compositions and uses thereof | MEDIMMUNE, LLC (US) | 2013-07-02 | — | — | US | claimed |
| EP-1588173-A2 | AFFINITY FISHING FOR LIGANDS AND PROTEINS RECEPTORS | Carlsberg A/S (DK) | 2005-10-26 | — | — | EP | claimed |
| WO-2004062553-A2 | AFFINITY SCREENING USING “ONE-BEAD-ONE-COMPOUND” LIBRARIES | CARLSBERG A/S (DK) | 2004-07-29 | — | — | WO | claimed |
| US-20040142379-A1 | Affinity fishing for ligands and proteins receptors | CARLSBERG RESEARCH LABORATORY (DK) | 2004-07-22 | — | — | US | claimed |
| WO-2003099322-A2 | IL-11 DERIVATIVES AND THERAPEUTIC USES THEREOF | ISIS INNOVATION LIMITED (GB) | 2003-12-04 | — | — | WO | claimed |
| EP-0828002-B1 | Modification of xylanase to improve thermophilicity, alkophilicity and thermostability | CA NAT RESEARCH COUNCIL (CA) | 2002-04-17 | — | — | EP | claimed |
| CN-114149432-B | Dual CLK/CDK1 inhibitors for cancer treatment | 斯坦福国际研究院 | 2024-07-05 | — | — | CN | disclosed |
| US-11964971-B2 | Methods and compositions for modulating splicing | SKYHAWK THERAPEUTICS, INC. (US) | 2024-04-23 | — | — | US | disclosed |
| CN-117327714-B | Australian wild cotton splicing factor GauSR45a and application thereof | 南京农业大学三亚研究院 | 2024-03-01 | — | — | CN | disclosed |
| US-11866705-B2 | Small cell lung cancer therapeutic agent containing oligonucleotide | Osaka Univerity (JP) | 2024-01-09 | — | — | US | disclosed |
| CN-117327714-A | Australian wild cotton splicing factor GauSR45a and application thereof | 南京农业大学三亚研究院 | 2024-01-02 | — | — | CN | disclosed |
| US-11858897-B2 | Substituted 6,11-dihydro-5H-benzo[b]carbazoles as inhibitors of ALK and SRPK | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2024-01-02 | — | — | US | disclosed |
| EP-1663219-A2 | USE OF INDOLE-DERIVED COMPOUNDS FOR THE PREPARATION OF A MEDICAMENT THAT CAN BE USED TO TREAT DISEASES RELATED TO THE SPLICING PROCESS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2006-06-07 | — | — | EP | disclosed |
| EP-1588173-A2 | AFFINITY FISHING FOR LIGANDS AND PROTEINS RECEPTORS | Carlsberg A/S (DK) | 2005-10-26 | — | — | EP | disclosed |
| CN-1657539-A | Human connective tissue growth factor mutant protein and its application | MEDICAL BIOGOGICAL INST CHINA (CN) | 2005-08-24 | — | — | CN | disclosed |
| WO-2005023255-A2 | USE OF INDOLE-DERIVED COMPOUNDS FOR THE PREPARATION OF A MEDICAMENT THAT CAN BE USED TO TREAT DISEASES RELATED TO THE SPLICING PROCESS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2005-03-17 | — | — | WO | disclosed |
| WO-2004062553-A2 | AFFINITY SCREENING USING “ONE-BEAD-ONE-COMPOUND” LIBRARIES | CARLSBERG A/S (DK) | 2004-07-29 | — | — | WO | disclosed |
| WO-1996030398-A1 | NOVEL AUTO ANTIGEN | MURDOCH UNIVERSITY (AU) | 1996-10-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11964971-B2 | Methods and compositions for modulating splicing | RBM17, SF3B1, SF3B5 | OTC 4185/4885DDAH1 2142/4885NOS2 2388/4885 |
| US-20210251963-A1 | UREA DERIVATIVES FOR USE IN THE TREATMENT OF SUBJECTS WITH ELEVATED EXPRESSION AND/OR ACTIVITY OF SRPK1 | SRPK1, SRPK3, HNRNPK | OTC 554/4885DDAH1 1947/4885NOS2 2254/4885 |
| US-11858897-B2 | Substituted 6,11-dihydro-5H-benzo[b]carbazoles as inhibitors of ALK and SRPK | SRPK3, SRPK1, SRPK2 | OTC 3023/4885DDAH1 3305/4885NOS2 3783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.