Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.43 |
| ▸ | OTC | P00480 | 1/20 | 0.35 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.34 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.34 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.34 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | DDAH1 | O94760 | 2/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | NPY4R | P50391 | 2/20 | 0.31 |
| ▸ | NPY1R | P25929 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6535302 | 0.93 | GSR (0.45) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL6378532 | 0.85 | NOS2 (0.40) | OTCNOS2DDAH1NOS3NOS1 | |
| Glycine SCHEMBL7934640 | 0.85 | GSR (0.38) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL28242594 | 0.85 | GSR (0.56) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL28527646 | 0.85 | GSR (0.56) | GSROTCGNAI3GNAO1GNAI1 | |
| Lysine SCHEMBL5579150 | 0.84 | GSR (0.49) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL1278143 | 0.84 | GSR (0.49) | GSROTCGNAI3GNAO1GNAI1 | |
| SCHEMBL11660913 | 0.84 | GNAI3 (0.46) | GSROTCGNAI3GNAO1GNAI1 | |
| SCHEMBL301607 | 0.84 | GNAI3 (0.46) | GSROTCGNAI3GNAO1GNAI1 | |
| SCHEMBL2899157 | 0.84 | OTC (0.43) | GSROTCNOS2DDAH1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10300167-B2 | Functionalized calcium phosphate artificial bone and joint compositions and methods of use and manufacture | Cabertech, Inc. (US) | 2019-05-28 | — | — | US | claimed |
| EP-2739265-A1 | FUNCTIONALIZED CALCIUM PHOSPHATE ARTIFICIAL BONE AND JOINT COMPOSITIONS AND METHODS OF USE AND MANUFACTURE | Cabertech, Inc. (US) | 2014-06-11 | — | — | EP | claimed |
| WO-2013016006-A1 | FUNCTIONALIZED CALCIUM PHOSPHATE ARTIFICIAL BONE AND JOINT COMPOSITIONS AND METHODS OF USE AND MANUFACTURE | Cabertech, Inc. (US) | 2013-01-31 | — | — | WO | claimed |
| US-20120087950-A1 | FUNCTIONALIZED CALCIUM PHOSPHATE ARTIFICIAL BONE AND JOINT COMPOSITIONS AND METHODS OF USE AND MANUFACTURE | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2012-04-12 | — | — | US | claimed |
| EP-2739265-B1 | FUNCTIONALIZED CALCIUM PHOSPHATE ARTIFICIAL BONE AND JOINT COMPOSITIONS AND METHODS OF USE AND MANUFACTURE | CABERTECH INC (US) | 2020-08-26 | — | — | EP | disclosed |
| US-10300167-B2 | Functionalized calcium phosphate artificial bone and joint compositions and methods of use and manufacture | Cabertech, Inc. (US) | 2019-05-28 | — | — | US | disclosed |
| EP-2739265-A1 | FUNCTIONALIZED CALCIUM PHOSPHATE ARTIFICIAL BONE AND JOINT COMPOSITIONS AND METHODS OF USE AND MANUFACTURE | Cabertech, Inc. (US) | 2014-06-11 | — | — | EP | disclosed |
| WO-2013016006-A1 | FUNCTIONALIZED CALCIUM PHOSPHATE ARTIFICIAL BONE AND JOINT COMPOSITIONS AND METHODS OF USE AND MANUFACTURE | Cabertech, Inc. (US) | 2013-01-31 | — | — | WO | disclosed |
| US-20120087950-A1 | FUNCTIONALIZED CALCIUM PHOSPHATE ARTIFICIAL BONE AND JOINT COMPOSITIONS AND METHODS OF USE AND MANUFACTURE | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2012-04-12 | — | — | US | disclosed |