Biphenyl

Biphenyl

SCHEMBL7934686

O=C(OC(=O)c1cccc(I)c1)c1cccc(I)c1.c1ccc(-c2ccccc2)cc1

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMO O15229 1/20 0.47
NPC1 O15118 2/20 0.45
RAB9A P51151 2/20 0.45
TDP1 Q9NUW8 2/20 0.44
MAPT P10636 1/20 0.44
HDAC8 Q9BY41 1/20 0.43
PDE4A P27815 1/20 0.41
F2 P00734 1/20 0.41
LMNA P02545 1/20 0.41
ERCC5 P28715 1/20 0.40
FEN1 P39748 1/20 0.40
AXL P30530 1/20 0.40
ATM Q13315 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
MTOR P42345 1/20 0.39
CTDSP1 Q9GZU7 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11264669 0.93 LMNA (0.48) RAB9ATDP1MAPTF2LMNA
SCHEMBL11264665 0.91 HDAC1 (0.42) TDP1F2LMNAATML3MBTL1
SCHEMBL29706640 0.85 KMO (0.64) KMONPC1RAB9ATDP1MAPT
SCHEMBL7654507 0.85 KMO (0.64) KMONPC1RAB9ATDP1MAPT
SCHEMBL28379117 0.81 HDAC1 (0.40) F2LMNAMTOR
Biphenyl SCHEMBL7862554 0.80 F2 (0.61) KMONPC1RAB9ATDP1MAPT
Biphenyl SCHEMBL6058549 0.79 PARP1 (0.52) KMONPC1RAB9AMAPTERCC5
SCHEMBL545343 0.78 LMNA (0.58) RAB9ATDP1MAPTF2LMNA
SCHEMBL6422675 0.77 MTOR (0.43) F2LMNAMTOR
SCHEMBL6572561 0.77 MAPT (0.47) KMOTDP1MAPTHDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1138712-A2 Polyarylene copolymers and proton-conductive membrane JSR Corporation (JP) 2001-10-04 EP disclosed