Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 2/20 | 0.30 |
| ▸ | HTR7 | P34969 | 2/20 | 0.30 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.30 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.30 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7926682 | 0.84 | — | — | |
| Hydrochloric Acid SCHEMBL4482811 | 0.84 | HTR1A (0.32) | MAPTPTPN1HTR1AHTR7NISCH | |
| SCHEMBL17415587 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL17386719 | 0.81 | — | — | |
| SCHEMBL5890131 | 0.81 | NPC1 (0.34) | NPC1MAPTRAB9ASMN1; SMN2ALOX5 | |
| Hydrochloric Acid SCHEMBL7936598 | 0.81 | HTR7 (0.32) | MAPTHTR1AHTR7NISCHKDM1A | |
| Hydrochloric Acid SCHEMBL4467654 | 0.78 | MAPT (0.35) | NPC1MAPTRAB9ASMN1; SMN2ALOX5 | |
| Hydrochloric Acid SCHEMBL4658126 | 0.78 | NPC1 (0.32) | NPC1MAPTRAB9ASMN1; SMN2ALOX5 | |
| SCHEMBL20943534 | 0.78 | HTR7 (0.35) | HTR1AHTR7NISCHKDM1A | |
| Hydrochloric Acid SCHEMBL31571612 | 0.78 | NPC1 (0.32) | NPC1MAPTRAB9ASMN1; SMN2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184402-B1 | RESOLUTION OF A STEREOISOMERIC MIXTURE OF SPECIFIC METALLOCENE COMPLEXES BRIDGED WITH A TRANSITION METAL HAVING AN OXYGEN BOND ATTACHED, I.E., A MU-OXO COMPLEX; HYDROLYSIS IN THE PRESENCE OF A BASE; SEPARATION OF MESO FORM FROM MIXES | CHISSO CORPORATION (JP) | 2001-02-06 | — | — | US | disclosed |