Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 3/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 2/20 | 0.30 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7217378 | 0.84 | — | — | |
| Hydrochloric Acid SCHEMBL4482811 | 0.84 | HTR1A (0.32) | HTR7SLC6A4SLC6A2SLC6A3KDM4E | |
| SCHEMBL5189192 | 0.82 | HTR7 (0.33) | HTR7SLC6A4DRD2SLC6A2SLC6A3 | |
| SCHEMBL20815319 | 0.81 | HTR7 (0.33) | HTR7SLC6A4DRD2KDM4EHTR1A | |
| Hydrochloric Acid SCHEMBL7935510 | 0.81 | NPC1 (0.32) | HTR7HTR1ANISCHMAPTKDM1A | |
| SCHEMBL4622630 | 0.79 | SLC6A4 (0.34) | HTR7SLC6A4DRD2SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL4065888 | 0.78 | HTR7 (0.35) | HTR7SLC6A4DRD2SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL6903687 | 0.78 | SLC6A4 (0.32) | HTR7SLC6A4DRD2SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL5691375 | 0.78 | SLC6A4 (0.32) | HTR7SLC6A4SLC6A2SLC6A3KDM4E | |
| Hydrochloric Acid SCHEMBL31126400 | 0.78 | SLC6A4 (0.32) | HTR7SLC6A4DRD2SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184402-B1 | RESOLUTION OF A STEREOISOMERIC MIXTURE OF SPECIFIC METALLOCENE COMPLEXES BRIDGED WITH A TRANSITION METAL HAVING AN OXYGEN BOND ATTACHED, I.E., A MU-OXO COMPLEX; HYDROLYSIS IN THE PRESENCE OF A BASE; SEPARATION OF MESO FORM FROM MIXES | CHISSO CORPORATION (JP) | 2001-02-06 | — | — | US | disclosed |