Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 13/20 | 0.58 |
| ▸ | EGFR | P00533 | 3/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | ABL2 | P42684 | 1/20 | 0.53 |
| ▸ | VCP | P55072 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | TERT | O14746 | 1/20 | 0.46 |
| ▸ | GALR2 | O43603 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL798036 | 0.84 | FBP1 (0.63) | FBP1EGFRABL1ABL2VCP | |
| SCHEMBL794027 | 0.84 | FBP1 (0.63) | FBP1EGFRABL1ABL2VCP | |
| SCHEMBL560424 | 0.79 | VCAM1 (0.67) | FBP1EGFRABL1ABL2VCP | |
| SCHEMBL560425 | 0.79 | VCAM1 (0.67) | FBP1EGFRABL1ABL2VCP | |
| SCHEMBL8010069 | 0.79 | EGFR (0.72) | FBP1EGFRABL1ABL2VCP | |
| SCHEMBL793177 | 0.79 | VCP (0.61) | FBP1EGFRABL1ABL2VCP | |
| SCHEMBL1975634 | 0.79 | FBP1 (0.58) | FBP1EGFRABL1ABL2VCP | |
| SCHEMBL807786 | 0.79 | VCP (0.61) | FBP1EGFRABL1ABL2VCP | |
| SCHEMBL1975635 | 0.79 | FBP1 (0.58) | FBP1EGFRABL1ABL2VCP | |
| SCHEMBL807974 | 0.76 | VCP (0.66) | FBP1EGFRABL1ABL2VCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627648-A1 | 17aHYDROXYLASE/C17,20-LYASE INHIBITORS | Novartis AG (CH) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012035078-A1 | 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS | NOVARTIS AG (CH) | 2012-03-22 | — | — | WO | disclosed |