SCHEMBL7936007

SCHEMBL7936007

COc1nc(F)cc(F)n1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.41
KMT2A Q03164 4/20 0.41
MAPT P10636 3/20 0.41
ATM Q13315 3/20 0.41
TSHR P16473 2/20 0.41
LMNA P02545 3/20 0.38
TDP1 Q9NUW8 1/20 0.38
ALDH1A1 P00352 6/20 0.36
HSD17B10 Q99714 2/20 0.36
MAPK1 P28482 2/20 0.33
NPC1 O15118 1/20 0.33
CYP1A2 P05177 1/20 0.33
RAB9A P51151 1/20 0.33
HTT P42858 3/20 0.32
KDM4E B2RXH2 1/20 0.32
USP2 O75604 1/20 0.32
HPGD P15428 1/20 0.32
RECQL P46063 1/20 0.32
GAA P10253 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12093323 0.85 MAPT (0.36) MEN1KMT2AMAPTATMTSHR
SCHEMBL16421175 0.85 LMNA (0.50) MEN1KMT2AMAPTATMTSHR
SCHEMBL4382412 0.72 ALDH1A1 (0.53) MEN1KMT2ALMNAALDH1A1NPC1
SCHEMBL17581229 0.72 TSHR (0.37) TSHR
SCHEMBL8102492 0.72 MEN1 (0.41) MEN1KMT2AMAPTTSHRLMNA
SCHEMBL9585452 0.72
SCHEMBL33145 0.71 ALDH1A1 (0.43) MEN1KMT2AMAPTATMTSHR
SCHEMBL23905835 0.71 ALDH1A1 (0.35) MEN1KMT2AMAPTATMTSHR
SCHEMBL7804792 0.71 MEN1 (0.34) MEN1KMT2AMAPTATMTSHR
SCHEMBL12724424 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6235904-B1 VALUABLE INTERMEDIATES FOR ORGANIC SYNTHESES, ESPECIALLY FOR PREPARING CROP PROTECTION AGENTS. BASF AKTIENGESELLSCHAFT (DE) 2001-05-22 US disclosed
US-5591694-A COMPOUND USED TO CONTROL UNDESIRABLE PLANT GROWTH BASF AKTIENGESELLSCHAFT (DE) 1997-01-07 US disclosed
EP-0446743-B1 Herbicidal sulfonylureas, process for their preparation and intermediates BASF AG (DE) 1995-08-02 EP disclosed
EP-0445642-B1 2-Amino-(fluoralkoxy-pyrimidines) and process for their preparation BASF AG (DE) 1995-07-12 EP disclosed
EP-0445644-B1 Trifluoro- respectively chlorodifluoromethoxy pyrimidines and process for their preparation BASF AG (DE) 1995-05-24 EP disclosed
EP-0600967-B1 HERBICIDAL SULPHONYL UREAS, PROCESS AND INTERMEDIATES FOR PRODUCING THE SAME BASF AG (DE) 1995-04-19 EP disclosed
EP-0378089-B1 Method for the preparation of 2-amino-4-fluoropyrimidine derivatives BASF AG (DE) 1994-06-29 EP disclosed
EP-0600967-A1 HERBICIDAL SULPHONYL UREAS, PROCESS AND INTERMEDIATES FOR PRODUCING THE SAME. BASF AG (DE) 1994-06-15 EP disclosed
EP-0378092-B1 Herbicidal sulfonyl ureas, process for preparing them and their use BASF AG (DE) 1994-05-11 EP disclosed
US-5283332-A 2-amino(fluoroalkoxy)pyrimidines and the preparation thereof BASF AKTIENGESELLSCHAFT (DE) 1994-02-01 US disclosed
US-5276007-A Herbicidal sulfonylureas BASF AKTIENGESELLSCHAFT (DE) 1994-01-04 US disclosed
US-5237063-A TRIFLUORO- AND CHLORODIFLUOROMETHOXYPYRIMIDINES AND THE PREPARATION THEREOF BASF AKTIENGESELLSCHAFT (DE) 1993-08-17 US disclosed
WO-1993005048-A2 HERBICIDAL SULPHONYL UREAS, PROCESS AND INTERMEDIATES FOR PRODUCING THE SAME BASF AKTIENGESELLSCHAFT (DE) 1993-03-18 WO disclosed
EP-0446743-A2 Herbicidal sulfonylureas, process for their preparation and intermediates BASF Aktiengesellschaft (DE) 1991-09-18 EP disclosed
EP-0445642-A1 2-Amino-(fluoralkoxy-pyrimidines) and process for their preparation BASF Aktiengesellschaft (DE) 1991-09-11 EP disclosed
EP-0445644-A1 Trifluoro- respectively chlorodifluoromethoxy pyrimidines and process for their preparation BASF Aktiengesellschaft (DE) 1991-09-11 EP disclosed
US-5011927-A Preparation of 2-amino-4-fluoropyrimidine derivatives BASF AKTIENGESELLSCHAFT (DE) 1991-04-30 US disclosed
EP-0378089-A1 Method for the preparation of 2-amino-4-fluoropyrimidine derivatives BASF Aktiengesellschaft (DE) 1990-07-18 EP disclosed
EP-0378092-A1 Herbicidal sulfonyl ureas, process for preparing them and their use BASF Aktiengesellschaft (DE) 1990-07-18 EP disclosed