SCHEMBL8102492

SCHEMBL8102492

CCOc1nc(F)cc(F)n1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.41
KMT2A Q03164 3/20 0.41
CYP1A2 P05177 1/20 0.41
POLB P06746 1/20 0.38
PDE4B Q07343 1/20 0.37
PDE4D Q08499 1/20 0.37
SMN1; SMN2 Q16637 2/20 0.36
MAT2A P31153 1/20 0.36
MAPK1 P28482 1/20 0.36
SCN9A Q15858 1/20 0.36
ALDH1A1 P00352 1/20 0.35
TSHR P16473 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
LMNA P02545 1/20 0.35
MAPT P10636 1/20 0.35
NQO1 P15559 1/20 0.35
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
CA1 P00915 2/20 0.33
CA2 P00918 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8111866 0.81 NCF1 (0.41)
SCHEMBL2135827 0.81 MEN1 (0.36) MEN1KMT2ACYP1A2POLBPDE4B
Propane SCHEMBL10857479 0.76 LMNA (0.32) MEN1KMT2ACYP1A2SMN1; SMN2ALDH1A1
SCHEMBL582039 0.76 MEN1 (0.52) MEN1KMT2ACYP1A2POLBPDE4B
SCHEMBL17581229 0.76 TSHR (0.37) TSHR
SCHEMBL10626112 0.75 MEN1 (0.43) MEN1KMT2ACYP1A2POLBPDE4B
SCHEMBL8345854 0.73 MEN1 (0.42) MEN1KMT2ACYP1A2POLBPDE4B
SCHEMBL3825486 0.73 MEN1 (0.42) MEN1KMT2ACYP1A2POLBPDE4B
SCHEMBL17581227 0.73 HTR7 (0.45) MAPT
SCHEMBL7936007 0.72 MEN1 (0.41) MEN1KMT2ACYP1A2MAPK1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114262300-A Preparation method of 2-ethoxy-4, 6-difluoropyrimidine 浙江伟锋药业有限公司 2022-04-01 CN claimed
CN-111303045-A Production process of 2-ethoxy-4, 6-difluoropyrimidine 温州大学 2020-06-19 CN claimed
CN-111217817-B Preparation method of triazolopyrimidine herbicide 山东潍坊润丰化工股份有限公司 2022-06-10 CN disclosed
CN-114262300-A Preparation method of 2-ethoxy-4, 6-difluoropyrimidine 浙江伟锋药业有限公司 2022-04-01 CN disclosed
CN-114262300-A Preparation method of 2-ethoxy-4, 6-difluoropyrimidine 浙江伟锋药业有限公司 2022-04-01 CN disclosed
CN-114262300-A Preparation method of 2-ethoxy-4, 6-difluoropyrimidine 浙江伟锋药业有限公司 2022-04-01 CN disclosed
CN-111303045-A Production process of 2-ethoxy-4, 6-difluoropyrimidine 温州大学 2020-06-19 CN disclosed
CN-111303045-A Production process of 2-ethoxy-4, 6-difluoropyrimidine 温州大学 2020-06-19 CN disclosed
CN-111303045-A Production process of 2-ethoxy-4, 6-difluoropyrimidine 温州大学 2020-06-19 CN disclosed
CN-111217817-A Preparation method of triazolopyrimidine herbicide 山东潍坊润丰化工股份有限公司 2020-06-02 CN disclosed
EP-3650443-A1 CONTINUOUS FLOW SYNTHESIS OF FLUORINATED OR NON-FLUORINATED PYRAZOLES Fujian Yongjing Technology Co., Ltd. (CN) 2020-05-13 EP disclosed
US-5488109-A 5-alkoxy[1,2,4]triazolo[1,5-c]pyrimidine-2(3H)--thione compounds and their use in the preparation of and 2-chlorosulfonyl-5-alkoxy[1,2,4]triazolo[1,5-c]-pyrimidine compounds DOWELANCO (US) 1996-01-30 US disclosed
US-5480991-A 2-Alkoxy-4-hydroazinopyrimidine compounds and their use in the preparation of 5-alkoxy-1,2,4-triazolo[4,3-c]pyrimidine-3(2H)-thione compounds DOWELANCO (US) 1996-01-02 US disclosed
EP-0678093-A1 5-ALKOXY-1,2,4-TRIAZOLO 4,3-C]PYRIMIDINE-3(2H)-THIONE COMPOUNDS AND THEIR USE IN THE PREPARATION OF 5-ALKOXY 1,2,4]TRIAZOLO 1,5-C]PYRIMIDINE-2(3H)-THIONE AND 3-HYDROCARBYLTHIO-5-ALKOXY-1,2,4-TRIAZOLO 4,3-C]PYRIMIDINE COMPOUNDS DOWELANCO (US) 1995-10-25 EP disclosed
EP-0678092-A1 5-ALKOXY 1,2,4]TRIAZOLO 1,5-C]PYRIMIDINE-2(3H)-THIONE COMPOUNDS AND THEIR USE IN THE PREPARATION OF 2,2'-DITHIOBIS(5-ALKOXY 1,2,4]TRIAZOLO 1,5-C]-PYRIMIDINE) AND 2-CHLOROSULFONYL-5-ALKOXY 1,2,4]TRIAZOLO 1,5-C]PYRIMIDINE COMPOUNDS DOWELANCO (US) 1995-10-25 EP disclosed
EP-0678094-A1 2-ALKOXY-4-HYDRAZINOPYRIMIDINE COMPOUNDS AND THEIR USE IN THE PREPARATION OF 5-ALKOXY-1,2-4-TRIAZOLO 4,3-C]PYRIMIDINE-3(2H)-THIONE COMPOUNDS DOWELANCO (US) 1995-10-25 EP disclosed
US-5461153-A 2-alkoxy-4-hydrazinopyrimidine compounds DOWELANCO (US) 1995-10-24 US disclosed
WO-1995012596-A1 5-ALKOXY[1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE-2(3H)-THIONE COMPOUNDS AND THEIR USE IN THE PREPARATION OF 2,2'-DITHIOBIS(5-ALKOXY[1,2,4]TRIAZOLO[1,5-C]-PYRIMIDINE) AND 2-CHLOROSULFONYL-5-ALKOXY[1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE COMPOUNDS DOWELANCO (US) 1995-05-11 WO disclosed
WO-1995012595-A1 5-ALKOXY-1,2,4-TRIAZOLO[4,3-C]PYRIMIDINE-3(2H)-THIONE COMPOUNDS AND THEIR USE IN THE PREPARATION OF 5-ALKOXY[1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE-2(3H)-THIONE AND 3-HYDROCARBYLTHIO-5-ALKOXY-1,2,4-TRIAZOLO[4,3-C]PYRIMIDINE COMPOUNDS DOWELANCO (US) 1995-05-11 WO disclosed
WO-1995012597-A1 2-ALKOXY-4-HYDRAZINOPYRIMIDINE COMPOUNDS AND THEIR USE IN THE PREPARATION OF 5-ALKOXY-1,2-4-TRIAZOLO[4,3-C]PYRIMIDINE-3(2H)-THIONE COMPOUNDS DOWELANCO (US) 1995-05-11 WO disclosed