Acetic Acid

Acetic Acid

SCHEMBL7936063

CC(=O)O.COc1ccc2c(C)cccc2c1

nearest known ligand 0.53

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Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 6/20 0.53
MTNR1B P49286 4/20 0.53
FLT3 P36888 1/20 0.51
CYP1A2 P05177 2/20 0.49
KDM4E B2RXH2 3/20 0.47
CYP2A6 P11509 1/20 0.47
IDH1 O75874 1/20 0.45
CDC25B P30305 1/20 0.44
MAPK1 P28482 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
ALDH1A1 P00352 1/20 0.44
HPGD P15428 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
HSD17B10 Q99714 1/20 0.44
PTGS1 P23219 1/20 0.44
AKR1C3 P42330 1/20 0.44
AKR1C2 P52895 1/20 0.44
HTR2C P28335 1/20 0.44
HTR2B P41595 1/20 0.44
CNR2 P34972 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL9228333 0.98 MTNR1A (0.52) MTNR1AMTNR1BFLT3CYP1A2KDM4E
Acetic Acid SCHEMBL27085298 0.91 MTNR1A (0.51) MTNR1AMTNR1BFLT3CYP1A2KDM4E
Acetic Acid SCHEMBL9228337 0.91 MTNR1A (0.51) MTNR1AMTNR1BFLT3CYP1A2CYP2A6
SCHEMBL5510892 0.90 CYP1A2 (0.59) MTNR1AMTNR1BFLT3CYP1A2KDM4E
SCHEMBL10458013 0.82 LMNA (0.54) MTNR1AMTNR1BFLT3CYP1A2KDM4E
Acetic Acid SCHEMBL7099991 0.79 CYP1A2 (0.76) FLT3CYP1A2KDM4ECYP2A6ALDH1A1
SCHEMBL2510203 0.79 CDC25B (0.64) MTNR1AMTNR1BKDM4ECDC25BNPSR1
SCHEMBL9747620 0.79 MTNR1A (0.55) MTNR1AMTNR1BCYP1A2KDM4ECYP2A6
SCHEMBL31613816 0.79 CDC25B (0.64) MTNR1AMTNR1BKDM4ECDC25BNPSR1
SCHEMBL23152686 0.79 MTNR1A (0.46) MTNR1AMTNR1BFLT3CYP1A2IDH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6242243-B1 PURE CULTURE; FOR PRODUCTION OF HYDROLASE ENZYME USEFUL IN EFFICIENT RESOLUTION OF (+)-6-METHOXY-ALPHA-METHYL NAPHTHALENE ACETIC ACID ALKYL ESTERS; PRODUCTION OF NAPROXEN COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2001-06-05 US disclosed