Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7936072 | 0.86 | — | — | |
| Hydrochloric Acid SCHEMBL7935531 | 0.80 | SLC6A3 (0.35) | GAANISCH | |
| Hydrochloric Acid SCHEMBL7926600 | 0.78 | HPGD (0.33) | NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7933131 | 0.71 | NPC1 (0.31) | NPC1GAARAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7933348 | 0.70 | — | — | |
| Hydrochloric Acid SCHEMBL7936918 | 0.68 | — | — | |
| SCHEMBL23893547 | 0.60 | PTGS2 (0.57) | NISCH | |
| SCHEMBL12806483 | 0.58 | NPC1 (0.35) | NPC1GAARAB9ASMN1; SMN2NISCH | |
| SCHEMBL8357761 | 0.58 | — | — | |
| SCHEMBL29547174 | 0.57 | ACHE (0.47) | NPC1RAB9ASMN1; SMN2NISCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184402-B1 | RESOLUTION OF A STEREOISOMERIC MIXTURE OF SPECIFIC METALLOCENE COMPLEXES BRIDGED WITH A TRANSITION METAL HAVING AN OXYGEN BOND ATTACHED, I.E., A MU-OXO COMPLEX; HYDROLYSIS IN THE PRESENCE OF A BASE; SEPARATION OF MESO FORM FROM MIXES | CHISSO CORPORATION (JP) | 2001-02-06 | — | — | US | disclosed |