SCHEMBL7936908

SCHEMBL7936908

FC(Cl)c1ccc(CCl)cc1

nearest known ligand 0.37

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.37
CA2 P00918 2/20 0.37
TSHR P16473 1/20 0.37
MAPK1 P28482 1/20 0.37
ATM Q13315 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
PGK1 P00558 2/20 0.32
PGK2 P07205 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17092743 0.82 CA1 (0.38) CA1CA2TSHRMAPK1ATM
SCHEMBL5655554 0.79 TSHR (0.46) CA1CA2TSHRMAPK1ATM
SCHEMBL9798184 0.76 CA1 (0.41) CA1CA2TSHRMAPK1ATM
SCHEMBL11698176 0.75 CA1 (0.37) CA1CA2TSHRMAPK1ATM
SCHEMBL19417918 0.75 CA1 (0.41) CA1CA2TSHRMAPK1ATM
SCHEMBL10179845 0.75 TSHR (0.41) CA1CA2TSHRMAPK1ATM
SCHEMBL4574471 0.75 TSHR (0.41) CA1CA2TSHRMAPK1ATM
SCHEMBL20560222 0.75 CA1 (0.33) CA1CA2
SCHEMBL97582 0.74 CA1 (0.52) CA1CA2TSHRTDP1
Hydrochloric Acid SCHEMBL19692755 0.73 LOXL2 (0.33) CA1CA2TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1138657-A1 Process for generating electrophiles from anions by reaction with electrophilic fluorinating agent AIR PRODUCTS AND CHEMICALS, INC. (US) 2001-10-04 EP disclosed
US-6270843-B1 REACTING A SALT COMPRISING ANIONIC FORM OF SUBSTITUENT WITH AN ELECTROPHILIC FLUORINATION AGENT TO PROVIDE AN ELECTROPHILE COMPRISING CATIONIC FORM OF SUBSTITUENT; ELECTROPHILICALLY SUBSTITUTING ELECTROPHILE ON SUBSTRATE AIR PRODUCTS AND CHEMICALS, INC. 2001-08-07 US disclosed